OBJECTIVE: Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing. RESULTS: Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing. CONCLUSION: MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.
OBJECTIVE: Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing. RESULTS: Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing. CONCLUSION:MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.
Authors: Stephan A Müller; Anja van der Smissen; Margarete von Feilitzsch; Ulf Anderegg; Stefan Kalkhof; Martin von Bergen Journal: J Mater Sci Mater Med Date: 2012-09-19 Impact factor: 3.896
Authors: Melyssa Lima de Medeiros; Irami Araújo-Filho; Efigênia Maria Nogueira da Silva; Wennye Scarlat de Sousa Queiroz; Ciro Dantas Soares; Maria Goretti Freire de Carvalho; Maria Aparecida Medeiros Maciel Journal: Lasers Med Sci Date: 2016-09-20 Impact factor: 3.161
Authors: Oliver C Thamm; Paola Koenen; Nicola Bader; Alina Schneider; Sebastian Wutzler; Edmund A M Neugebauer; Timo A Spanholtz Journal: Int Wound J Date: 2013-03-21 Impact factor: 3.315