Literature DB >> 1688544

Identification of virus components in circulating immune complexes isolated during hepatitis A virus infection.

H S Margolis1, O V Nainan.   

Abstract

Circulating immune complexes were isolated by conglutinin affinity chromatography during the course of hepatitis A virus infection in a chimpanzee. Characterization of circulating immune complexes showed that most of the hepatitis A virus-specific antibody was IgM, that IgG was present and that C3d and fibronectin were also present. Hepatitis A virus capsid polypeptides were identified in the circulating immune complexes and polypeptides in the molecular weight range of 63 to 67 kDa having immunological determinants common to both C3d and hepatitis A virus. Hepatitis A virus-RNA was detected in these circulating immune complexes using the polymerase chain reaction for in vitro amplification of nucleic acid and suggests the circulating immune complexes contain intact virus.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1688544     DOI： 10.1002/hep.1840110107

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


  10 in total

Review 1.  Immunological abnormalities and hepatotropic viral infections.

Authors:  I G McFarlane
Journal:  Clin Exp Immunol       Date:  1992-03       Impact factor: 4.330

Review 2.  Diagnosis of hepatitis a virus infection: a molecular approach.

Authors:  Omana V Nainan; Guoliang Xia; Gilberto Vaughan; Harold S Margolis
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

3.  Detection of hepatitis A virus RNA in oyster meat.

Authors:  T L Cromeans; O V Nainan; H S Margolis
Journal:  Appl Environ Microbiol       Date:  1997-06       Impact factor: 4.792

Review 4.  Application of nucleic acid amplification in clinical microbiology.

Authors:  G Lisby
Journal:  Mol Biotechnol       Date:  1999-08       Impact factor: 2.695

Review 5.  Hepatitis A: old and new.

Authors:  J A Cuthbert
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

6.  Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus.

Authors:  G Kaplan; A Totsuka; P Thompson; T Akatsuka; Y Moritsugu; S M Feinstone
Journal:  EMBO J       Date:  1996-08-15       Impact factor: 11.598

7.  Hepatitis A virus-specific immunoglobulin A mediates infection of hepatocytes with hepatitis A virus via the asialoglycoprotein receptor.

Authors:  A Dotzauer; U Gebhardt; K Bieback; U Göttke; A Kracke; J Mages; S M Lemon; A Vallbracht
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

Review 8.  Severe acute hepatitis A associated with acute pure red cell aplasia.

Authors:  S Tomida; Y Matsuzaki; M Nishi; T Ikegami; T Chiba; M Abei; N Tanaka; T Osuga; Y Sato; T Abe
Journal:  J Gastroenterol       Date:  1996-08       Impact factor: 7.527

9.  A multistate outbreak of hepatitis A caused by the consumption of raw oysters.

Authors:  J C Desenclos; K C Klontz; M H Wilder; O V Nainan; H S Margolis; R A Gunn
Journal:  Am J Public Health       Date:  1991-10       Impact factor: 9.308

10.  Factors for predicting positive results for anti-HAV IgM retesting among initially seronegative patients.

Authors:  Hyun Phil Shin; Joung Il Lee; Sung Won Jung; Jae Myung Cha; Kwang Ro Joo; So Young Kang
Journal:  Dig Dis Sci       Date:  2010-01-27       Impact factor: 3.199
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.