Literature DB >> 168841

Guanidine and neuromuscular transmission. II. Effect on transmitter release in response to repetitive nerve stimulation.

M A Kamenskaya, D Elmqvist, S Thesleff.   

Abstract

The effect of guanidine on the neuromuscular transmission in human intercostal and mouse diaphragm muscle in vitro during repetitive nerve stimulation was studied. The drug greatly increased the release of acetylcholine (ACh) quanta by nerve impulses at low frequencies of nerve stimulation and at the beginning of tetani at high frequencies of stimulation. The effect was shown to be produced by an increase in fractional release from an unchanged store of ACh quanta available fro immediate release. This seems to explain why guanidine has a poor therapeutic effect in myasthenia gravis but a good effect in the myasthenic syndrome.

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Year:  1975        PMID： 168841     DOI： 10.1001/archneur.1975.00490500030002

Source DB:  PubMed          Journal:  Arch Neurol        ISSN： 0003-9942


  13 in total

1.  Synaptic vesicle dynamics in rat fast and slow motor nerve terminals.

Authors:  B Reid; C R Slater; G S Bewick
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

2.  Effects of guanidine on synaptic transmission in the spinal cord of the frog.

Authors:  P Grafe; U Sonnhof
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-12       Impact factor: 3.000

3.  DPAGT1 myasthenia and myopathy: genetic, phenotypic, and expression studies.

Authors:  Duygu Selcen; Xin-Ming Shen; Joan Brengman; Ying Li; Anthony A Stans; Eric Wieben; Andrew G Engel
Journal:  Neurology       Date:  2014-04-23       Impact factor: 9.910

4.  Congenital myasthenic syndrome-associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner.

Authors:  Bisei Ohkawara; XinMing Shen; Duygu Selcen; Mohammad Nazim; Vera Bril; Mark A Tarnopolsky; Lauren Brady; Sae Fukami; Anthony A Amato; Uluc Yis; Kinji Ohno; Andrew G Engel
Journal:  JCI Insight       Date:  2020-04-09

5.  PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome.

Authors:  Luc Régal; Xin-Ming Shen; Duygu Selcen; Chantal Verhille; Sandra Meulemans; John W M Creemers; Andrew G Engel
Journal:  Neurology       Date:  2014-03-07       Impact factor: 9.910

6.  A novel fast-channel myasthenia caused by mutation in β subunit of AChR reveals subunit-specific contribution of the intracellular M1-M2 linker to channel gating.

Authors:  Xin-Ming Shen; Li Di; Shelley Shen; Yuying Zhao; Ann M Neumeyer; Duygu Selcen; Steven M Sine; Andrew G Engel
Journal:  Exp Neurol       Date:  2020-06-03       Impact factor: 5.330

7.  Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability.

Authors:  Xin-Ming Shen; Duygu Selcen; Joan Brengman; Andrew G Engel
Journal:  Neurology       Date:  2014-11-07       Impact factor: 9.910

8.  A study of tetanic and post-tetanic potentiation of miniature end-plate potentials at the frog neuromuscular junction.

Authors:  A Lev-Tov; R Rahamimoff
Journal:  J Physiol       Date:  1980-12       Impact factor: 5.182

9.  Effect of guanidine on release of noradrenaline from the perfused spleen of the cat.

Authors:  J Hirsch; S M Kirpekar; J C Prat
Journal:  Br J Pharmacol       Date:  1979-08       Impact factor: 8.739

10.  The relationship between twitch depression and twitch fade during neuromuscular block produced by vecuronium: correlation with the release of acetylcholine.

Authors:  Shashi B Bhatt; Jack Kohl; Anton Amann; Vladimir Nigrovic
Journal:  Theor Biol Med Model       Date:  2007-07-16       Impact factor: 2.432
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