INTRODUCTION AND DEVELOPMENT: Subthalamic stimulation is a therapeutic option that can be used to treat advanced cases of Parkinson's disease. However, psychiatric or cognitive disorders have been reported in some patients treated using this technique. Age and a long disease history are two important risk factors for the appearance of these problems. The complications that have been reported include cases of depression, apathy, manias and psychosis. Surgery can also exacerbate the syndrome of addiction to levodopa that is sometimes observed. In contrast, sleep disorders usually improve with this technique. As far as the cognitive sphere is concerned, verbal fluency has been seen to deteriorate and the executive functions become impaired in patients over 69 years of age. These disorders are usually due to a number of different causes and have been attributed to the action of stimulating areas close to the subthalamic nucleus, to the presence of previously existing cognitive or psychiatric problems, to unrealistic expectations about this technique or to the individual's inability to adapt to the functional situation after surgery. CONCLUSIONS: Although generally speaking these disorders are not usually serious, they must be borne in mind so that adequate treatment can be indicated.
INTRODUCTION AND DEVELOPMENT: Subthalamic stimulation is a therapeutic option that can be used to treat advanced cases of Parkinson's disease. However, psychiatric or cognitive disorders have been reported in some patients treated using this technique. Age and a long disease history are two important risk factors for the appearance of these problems. The complications that have been reported include cases of depression, apathy, manias and psychosis. Surgery can also exacerbate the syndrome of addiction to levodopa that is sometimes observed. In contrast, sleep disorders usually improve with this technique. As far as the cognitive sphere is concerned, verbal fluency has been seen to deteriorate and the executive functions become impaired in patients over 69 years of age. These disorders are usually due to a number of different causes and have been attributed to the action of stimulating areas close to the subthalamic nucleus, to the presence of previously existing cognitive or psychiatric problems, to unrealistic expectations about this technique or to the individual's inability to adapt to the functional situation after surgery. CONCLUSIONS: Although generally speaking these disorders are not usually serious, they must be borne in mind so that adequate treatment can be indicated.
Authors: Jenna Dietz; Angela M Noecker; Cameron C McIntyre; Ania Mikos; Dawn Bowers; Kelly D Foote; Michael S Okun Journal: Brain Stimul Date: 2012-06-16 Impact factor: 8.955
Authors: Alan Ruttenberg; Tim Clark; William Bug; Matthias Samwald; Olivier Bodenreider; Helen Chen; Donald Doherty; Kerstin Forsberg; Yong Gao; Vipul Kashyap; June Kinoshita; Joanne Luciano; M Scott Marshall; Chimezie Ogbuji; Jonathan Rees; Susie Stephens; Gwendolyn T Wong; Elizabeth Wu; Davide Zaccagnini; Tonya Hongsermeier; Eric Neumann; Ivan Herman; Kei-Hoi Cheung Journal: BMC Bioinformatics Date: 2007-05-09 Impact factor: 3.169