Literature DB >> 16883415

Skeletal diversity construction via a branching synthetic strategy.

Emma E Wyatt1, Suzanne Fergus, Warren R J D Galloway, Andreas Bender, David J Fox, Alleyn T Plowright, Alan S Jessiman, Martin Welch, David R Spring.   

Abstract

A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated.

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Year:  2006        PMID： 16883415     DOI： 10.1039/b607710b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

2.  Chemically engineered extracts as an alternative source of bioactive natural product-like compounds.

Authors:  Silvia N López; I Ayelen Ramallo; Manuel Gonzalez Sierra; Susana A Zacchino; Ricardo L E Furlan
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-27       Impact factor: 11.205

3.  Chiral cyclopropenyl ketones: reactive and selective Diels-Alder dienophiles.

Authors:  Laural A Fisher; Natalee J Smith; Joseph M Fox
Journal:  J Org Chem       Date:  2013-03-11       Impact factor: 4.354

4.  Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

Authors:  Zhiming Wang; Sabrina Castellano; Sape S Kinderman; Christian E Argueta; Anwar B Beshir; Gabriel Fenteany; Ohyun Kwon
Journal:  Chemistry       Date:  2010-11-09       Impact factor: 5.236

5.  The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.

Authors:  Renato A Bauer; Christine M DiBlasi; Derek S Tan
Journal:  Org Lett       Date:  2010-05-07       Impact factor: 6.005

6.  Skeletal and Appendage Diversity as Design Elements in the Synthesis of a Discovery Library of Nonaromatic Polycyclic 5-Iminooxazolidin-2-ones, Hydantoins, and Acylureas.

Authors:  S Werner; D M Turner; P G Chambers; K M Brummond
Journal:  Tetrahedron       Date:  2008-07-14       Impact factor: 2.457

7.  Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.

Authors:  Alan Rolfe; Gerald H Lushington; Paul R Hanson
Journal:  Org Biomol Chem       Date:  2010-03-16       Impact factor: 3.876

8.  Skeletal diversification via heteroatom linkage control: preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols.

Authors:  Thomas O Painter; Jonathon R Bunn; Frank J Schoenen; Justin T Douglas; Victor W Day; Conrad Santini
Journal:  J Org Chem       Date:  2013-04-01       Impact factor: 4.354

9.  Selective syntheses of Δ(α,β) and Δ(β,γ) butenolides from allylic cyclopropenecarboxylates via tandem ring expansion/[3,3]-sigmatropic rearrangements.

Authors:  Xiaocong Xie; Yi Li; Joseph M Fox
Journal:  Org Lett       Date:  2013-03-20       Impact factor: 6.005

10.  Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles.

Authors:  David M Arnold; Matthew G Laporte; Shelby M Anderson; Peter Wipf
Journal:  Tetrahedron       Date:  2013-09-09       Impact factor: 2.457
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