Literature DB >> 1688340

Dopa decarboxylase activity of the living human brain.

A Gjedde1, J Reith, S Dyve, G Léger, M Guttman, M Diksic, A Evans, H Kuwabara.   

Abstract

Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculated the enzyme activity, relative to its Km, with a kinetic model that yielded the relative rate of conversion of 6-[18F]fluoro-L-dopa to [18F]fluorodopamine. Regional values of relative dopa decarboxylase activity ranged from nil in occipital cortex to 1.9 h-1 in caudate nucleus and putamen, in agreement with values obtained in vitro.

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Year:  1991        PMID： 1688340      PMCID： PMC51310          DOI： 10.1073/pnas.88.7.2721

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

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2.  Blood-brain transfer and metabolism of 6-[18F]fluoro-L-dopa in rat.

Authors:  J Reith; S Dyve; H Kuwabara; M Guttman; M Diksic; A Gjedde
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3.  Anatomical-functional correlation using an adjustable MRI-based region of interest atlas with positron emission tomography.

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Journal:  J Cereb Blood Flow Metab       Date:  1988-08       Impact factor: 6.200

4.  Striatonigral degeneration. Response to levodopa therapy with pathological and neurochemical correlation.

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Review 5.  Regulation of tryptophan and tyrosine hydroxylase.

Authors:  W Lovenberg; S J Victor
Journal:  Life Sci       Date:  1974-06-16       Impact factor: 5.037

6.  Cerebral metabolism of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine in the primate.

Authors:  G Firnau; S Sood; R Chirakal; C Nahmias; E S Garnett
Journal:  J Neurochem       Date:  1987-04       Impact factor: 5.372

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Authors:  L Oreland; Y Arai; A Stenström
Journal:  Acta Neurol Scand Suppl       Date:  1983

8.  Neurochemical insights into monoamine oxidase inhibitors, with special reference to deprenyl (selegiline).

Authors:  P Riederer; K Jellinger
Journal:  Acta Neurol Scand Suppl       Date:  1983

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Authors:  E S Garnett; G Firnau; C Nahmias
Journal:  Nature       Date:  1983 Sep 8-14       Impact factor: 49.962

10.  Analysis of emission tomographic scan data: limitations imposed by resolution and background.

Authors:  R M Kessler; J R Ellis; M Eden
Journal:  J Comput Assist Tomogr       Date:  1984-06       Impact factor: 1.826
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  23 in total

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Journal:  Eur J Nucl Med Mol Imaging       Date:  2002-03-22       Impact factor: 9.236

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3.  Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo.

Authors:  Daniel P Eisenberg; Philip D Kohn; Catherine E Hegarty; Angela M Ianni; Bhaskar Kolachana; Michael D Gregory; Joseph C Masdeu; Karen F Berman
Journal:  Neuropsychopharmacology       Date:  2016-02-29       Impact factor: 7.853

Review 4.  Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme.

Authors:  M D Berry; A V Juorio; X M Li; A A Boulton
Journal:  Neurochem Res       Date:  1996-09       Impact factor: 3.996

5.  Elevated dopa decarboxylase activity in living brain of patients with psychosis.

Authors:  J Reith; C Benkelfat; A Sherwin; Y Yasuhara; H Kuwabara; F Andermann; S Bachneff; P Cumming; M Diksic; S E Dyve; P Etienne; A C Evans; S Lal; M Shevell; G Savard; D F Wong; G Chouinard; A Gjedde
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

6.  Positron emission tomographic measure of brain dopamine dependence to nicotine as a model of drugs of abuse.

Authors:  Edward F Domino; Hideo Tsukada; Norihiro Harada
Journal:  Psychopharmacology (Berl)       Date:  2009-01-10       Impact factor: 4.530

7.  In-vivo measurement of LDOPA uptake, dopamine reserve and turnover in the rat brain using [18F]FDOPA PET.

Authors:  Matthew D Walker; Katherine Dinelle; Rick Kornelsen; Siobhan McCormick; Chenoa Mah; James E Holden; Matthew J Farrer; A Jon Stoessl; Vesna Sossi
Journal:  J Cereb Blood Flow Metab       Date:  2012-08-29       Impact factor: 6.200

8.  Behavioral and frontal cortical metabolic effects of apomorphine and muscimol microinjections into the mediodorsal thalamic nucleus.

Authors:  K A Young; P B Hicks; P K Randall; R E Wilcox
Journal:  J Neural Transm Gen Sect       Date:  1994

9.  Positron emission tomographic studies on aromatic L-amino acid decarboxylase activity in vivo for L-dopa and 5-hydroxy-L-tryptophan in the monkey brain.

Authors:  P Hartvig; J Tedroff; K J Lindner; P Bjurling; C W Chang; H Tsukada; Y Watanabe; B Långström
Journal:  J Neural Transm Gen Sect       Date:  1993

10.  DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study.

Authors:  M Ernst; A J Zametkin; J A Matochik; P H Jons; R M Cohen
Journal:  J Neurosci       Date:  1998-08-01       Impact factor: 6.167
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