Justin F Fraser1, Philip E Stieg. 1. Department of Neurological Surgery, Cornell University-Weill Medical College New York, Presbyterian Hospital, New York, New York, USA.
Abstract
OBJECTIVE: Hyponatremia is an important and common electrolyte disorder in critically ill neurosurgical patients that has been reported in association with a number of different primary diagnoses. The correct diagnosis of the pathophysiological cause is vital because it dramatically alters the treatment approach. METHODS: We review the epidemiology and presentation of patients with hyponatremia, the pathophysiology of the disorder with respect to sodium and fluid balance, and the diagnostic procedures for determining the correct cause. RESULTS: We then present the various treatment options, including discussion of one of the newest groups of agents, the arginine vasopressin receptor antagonists, currently under study for the treatment of hyponatremia in neurosurgical patients. CONCLUSION: Hyponatremia is a serious comorbidity in neurosurgical patients that requires particular attention as its treatment varies by cause and its consequences can affect neurological outcome.
OBJECTIVE:Hyponatremia is an important and common electrolyte disorder in critically ill neurosurgicalpatients that has been reported in association with a number of different primary diagnoses. The correct diagnosis of the pathophysiological cause is vital because it dramatically alters the treatment approach. METHODS: We review the epidemiology and presentation of patients with hyponatremia, the pathophysiology of the disorder with respect to sodium and fluid balance, and the diagnostic procedures for determining the correct cause. RESULTS: We then present the various treatment options, including discussion of one of the newest groups of agents, the arginine vasopressin receptor antagonists, currently under study for the treatment of hyponatremia in neurosurgical patients. CONCLUSION:Hyponatremia is a serious comorbidity in neurosurgical patients that requires particular attention as its treatment varies by cause and its consequences can affect neurological outcome.
Authors: Alisa M Shea; Bradley G Hammill; Lesley H Curtis; Lynda A Szczech; Kevin A Schulman Journal: J Am Soc Nephrol Date: 2008-01-23 Impact factor: 10.121
Authors: Elena L Sorba; Victor E Staartjes; Stefanos Voglis; Lazar Tosic; Giovanna Brandi; Oliver Tschopp; Carlo Serra; Luca Regli Journal: Neurosurg Rev Date: 2020-06-24 Impact factor: 3.042
Authors: Robert S Eisinger; Zachary A Sorrentino; Brandon Lucke-Wold; Sonya Zhou; Brooke Barlow; Brian Hoh; Carolina B Maciel; Katharina M Busl Journal: Brain Inj Date: 2022-03-30 Impact factor: 2.167