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Literature DB >> 16880998

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

Luke A McNeill¹, Emily Flashman, Matthew R G Buck, Kirsty S Hewitson, Ian J Clifton, Gunnar Jeschke, Timothy D W Claridge, Dominic Ehrismann, Neil J Oldham, Christopher J Schofield.

Abstract

Regulation of the hypoxic response in humans is regulated by the post-translational hydroxylation of hypoxia inducible transcription factor; a recombinant form of a human prolyl-4-hydroxylase (PHD2) was characterised and shown to have an unexpectedly high affinity for, and to copurify with endogenous levels of, its Fe(ii) cofactor and 2-oxoglutarate cosubstrate.

Entities: Chemical

Mesh：

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Year: 2005 PMID： 16880998 DOI： 10.1039/b511249b

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

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Cited

35 in total

Review 1. The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Authors: Anthony R Cyr; Frederick E Domann
Journal: Antioxid Redox Signal Date: 2011-02-05 Impact factor: 8.401

2. Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.

Authors: Sunil Kumar; Ashok Kumar Patel
Journal: Mol Biotechnol Date: 2020-02 Impact factor: 2.695

3. At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2α.

Authors: Frank S Lee
Journal: J Clin Invest Date: 2018-12-10 Impact factor: 14.808

4. Vitamin C is dispensable for oxygen sensing in vivo.

Authors: Katarzyna J Nytko; Nobuyo Maeda; Philipp Schläfli; Patrick Spielmann; Roland H Wenger; Daniel P Stiehl
Journal: Blood Date: 2011-02-23 Impact factor: 22.113

Review 5. The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment.

Authors: Osigbemhe Iyalomhe; Sabina Swierczek; Ngozi Enwerem; Yuanxiu Chen; Monica O Adedeji; Joanne Allard; Oyonumo Ntekim; Sheree Johnson; Kakra Hughes; Philip Kurian; Thomas O Obisesan
Journal: Cell Mol Neurobiol Date: 2016-11-17 Impact factor: 5.046

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

Review 1. The redox basis of epigenetic modifications: from mechanisms to functional consequences.

2. Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.

3. At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2α.

4. Vitamin C is dispensable for oxygen sensing in vivo.

Review 5. The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment.

6. Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.

7. The serine protease TMPRSS6 is required to sense iron deficiency.

8. Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns.

Review 9. Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.

Review 10. Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.