Literature DB >> 16880974

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

Zuben E Sauna1, Suneet Shukla, Suresh V Ambudkar.   

Abstract

Disulfiram, a drug used to treat alcoholism, has recently been indicated to play a primary as well as an adjuvant role in the treatment of many cancers and in the reversal of fungal drug-resistance. This review discusses the molecular mechanism of action of disulfiram and its potential use in the treatment of human cancers and fungal infections.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16880974     DOI： 10.1039/b504392a

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  24 in total

1.  Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans.

Authors:  Marian E Helsel; Elizabeth J White; Sayyeda Zeenat A Razvi; Bruno Alies; Katherine J Franz
Journal:  Metallomics       Date:  2017-01-25       Impact factor: 4.526

2.  Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.

Authors:  Ghali Brahemi; Fathima R Kona; Annalisa Fiasella; Daniela Buac; Jitka Soukupová; Andrea Brancale; Angelika M Burger; Andrew D Westwell
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

3.  Determination of GABA, glutamate and carbamathione in brain microdialysis samples by capillary electrophoresis with fluorescence detection.

Authors:  Swetha Kaul; Morris D Faiman; Craig E Lunte
Journal:  Electrophoresis       Date:  2011-01       Impact factor: 3.535

4.  Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors.

Authors:  Seung Ah Choi; Jung Won Choi; Kyu-Chang Wang; Ji Hoon Phi; Ji Yeoun Lee; Kyung Duk Park; Dayoung Eum; Sung-Hye Park; Il Han Kim; Seung-Ki Kim
Journal:  Neuro Oncol       Date:  2014-11-04       Impact factor: 12.300

5.  Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth.

Authors:  Jianqing Lin; Michael C Haffner; Yonggang Zhang; Byron H Lee; W Nathaniel Brennen; Justin Britton; Sushant K Kachhap; Joong Sup Shim; Jun O Liu; William G Nelson; Srinivasan Yegnasubramanian; Michael A Carducci
Journal:  Prostate       Date:  2010-08-31       Impact factor: 4.104

6.  Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Authors:  Sifei Xing; Cynthia K Bullen; Neeta S Shroff; Liang Shan; Hung-Chih Yang; Jordyn L Manucci; Shridhar Bhat; Hao Zhang; Joseph B Margolick; Thomas C Quinn; David M Margolis; Janet D Siliciano; Robert F Siliciano
Journal:  J Virol       Date:  2011-04-06       Impact factor: 5.103

7.  Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.

Authors:  Rebecca M Johnson; Chris Allen; Sandra D Melman; Anna Waller; Susan M Young; Larry A Sklar; Karlett J Parra
Journal:  Anal Biochem       Date:  2009-12-14       Impact factor: 3.365

Review 8.  Pharmacological means of reducing human drug dependence: a selective and narrative review of the clinical literature.

Authors:  Shih-Ku Lin
Journal:  Br J Clin Pharmacol       Date:  2014-02       Impact factor: 4.335

9.  Repositioning disulfiram as a radiosensitizer against atypical teratoid/rhabdoid tumor.

Authors:  Young Eun Lee; Seung Ah Choi; Pil Ae Kwack; Hak Jae Kim; Il Han Kim; Kyu-Chang Wang; Ji Hoon Phi; Ji Yeoun Lee; Sangjoon Chong; Sung-Hye Park; Kyung Duk Park; Do Won Hwang; Kyeung Min Joo; Seung-Ki Kim
Journal:  Neuro Oncol       Date:  2017-08-01       Impact factor: 12.300

Review 10.  Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi.

Authors:  Lucie Peyclit; Hanane Yousfi; Jean-Marc Rolain; Fadi Bittar
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-20
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.