Literature DB >> 16880746

CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression.

Guikai Wu1, Wen-Hwa Lee.   

Abstract

CtIP was originally characterized as an interacting protein for the transcriptional corepressor CtBP. In addition to transcriptional regulation, CtIP plays an important role in the DNA damage response and cell cycle checkpoint control. Recent evidence points to a viral factor-like S phase promoting activity of CtIP in counteracting Rb repression to facilitate E2F-directed transactivation during the G(1)/S transition. Genetic studies in mice revealed the haploid insufficiency of CtIP in suppressing tumorigenesis associated with shortened life span. Thus, CtIP emerges as a multivalent adaptor that connects cell cycle checkpoint control, transcriptional regulation and tumor suppression.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16880746     DOI： 10.4161/cc.5.15.3127

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  18 in total

1.  Human CtIP promotes DNA end resection.

Authors:  Alessandro A Sartori; Claudia Lukas; Julia Coates; Martin Mistrik; Shuang Fu; Jiri Bartek; Richard Baer; Jiri Lukas; Stephen P Jackson
Journal:  Nature       Date:  2007-10-28       Impact factor: 49.962

2.  Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Authors:  Oliver Limbo; Charly Chahwan; Yoshiki Yamada; Robertus A M de Bruin; Curt Wittenberg; Paul Russell
Journal:  Mol Cell       Date:  2007-10-12       Impact factor: 17.970

Review 3.  MRN and the race to the break.

Authors:  Agnieszka Rupnik; Noel F Lowndes; Muriel Grenon
Journal:  Chromosoma       Date:  2009-10-28       Impact factor: 4.316

Review 4.  DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

Authors:  Zhongsheng You; Julie M Bailis
Journal:  Trends Cell Biol       Date:  2010-05-03       Impact factor: 20.808

5.  The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression.

Authors:  F Zhang; H Tang; Y Jiang; Z Mao
Journal:  Oncogene       Date:  2017-05-08       Impact factor: 9.867

Review 6.  DNA resection in eukaryotes: deciding how to fix the break.

Authors:  Pablo Huertas
Journal:  Nat Struct Mol Biol       Date:  2010-01       Impact factor: 15.369

7.  A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination.

Authors:  Alexandra Penkner; Zsuzsanna Portik-Dobos; Lois Tang; Ralf Schnabel; Maria Novatchkova; Verena Jantsch; Josef Loidl
Journal:  EMBO J       Date:  2007-11-15       Impact factor: 11.598

8.  CtIP links DNA double-strand break sensing to resection.

Authors:  Zhongsheng You; Linda Z Shi; Quan Zhu; Peng Wu; You-Wei Zhang; Andrew Basilio; Nina Tonnu; Inder M Verma; Michael W Berns; Tony Hunter
Journal:  Mol Cell       Date:  2009-12-25       Impact factor: 17.970

9.  Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

Authors:  Yufuko Akamatsu; Yasuto Murayama; Takatomi Yamada; Tomofumi Nakazaki; Yasuhiro Tsutsui; Kunihiro Ohta; Hiroshi Iwasaki
Journal:  Mol Cell Biol       Date:  2008-03-31       Impact factor: 4.272

10.  CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.

Authors:  Arne Nedergaard Kousholt; Kasper Fugger; Saskia Hoffmann; Brian D Larsen; Tobias Menzel; Alessandro A Sartori; Claus Storgaard Sørensen
Journal:  J Cell Biol       Date:  2012-06-25       Impact factor: 10.539
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.