Literature DB >> 16879962

Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand.

Scott E Wolkenberg1, Zhijian Zhao, Marianna Kapitskaya, Andrea L Webber, Konstantin Petrukhin, Yui Sing Tang, Dennis C Dean, George D Hartman, Craig W Lindsley.   

Abstract

Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.

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Year:  2006        PMID： 16879962     DOI： 10.1016/j.bmcl.2006.07.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

Review 1.  Orphan nuclear receptors as targets for drug development.

Authors:  Subhajit Mukherjee; Sridhar Mani
Journal:  Pharm Res       Date:  2010-04-06       Impact factor: 4.200

Review 2.  Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.

Authors:  Douglas Forrest; Anand Swaroop
Journal:  Mol Endocrinol       Date:  2012-05-03

Review 3.  The orphan nuclear receptors at their 25-year reunion.

Authors:  Shannon E Mullican; Joanna R Dispirito; Mitchell A Lazar
Journal:  J Mol Endocrinol       Date:  2013-11-26       Impact factor: 5.098

4.  Synthesis of benzimidazoles containing pyrazole group and quantum chemistry calculation of their spectroscopic properties and electronic structure.

Authors:  Tie-gang Ren; Hong-bin Cheng; Jing-lai Zhang; Wei-jie Li; Jia Guo; Li-rong Yang
Journal:  J Fluoresc       Date:  2011-08-09       Impact factor: 2.217

5.  In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3.

Authors:  Qiong Qin; Anna Knapinska; Nicoleta Dobri; Franck Madoux; Peter Chase; Peter Hodder; Konstantin Petrukhin
Journal:  J Ocul Pharmacol Ther       Date:  2012-10-25       Impact factor: 2.671

6.  Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation.

Authors:  Zhi Wen; Dohun Pyeon; Yidan Wang; Paul Lambert; Wei Xu; Paul Ahlquist
Journal:  Mol Cell Biol       Date:  2011-10-24       Impact factor: 4.272

Review 7.  Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases.

Authors:  Mayur Choudhary; Goldis Malek
Journal:  J Biomol Screen       Date:  2016-07-28

8.  IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.

Authors:  Z Zhao; L Wang; W Xu
Journal:  Oncogene       Date:  2014-04-21       Impact factor: 9.867

Review 9.  Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction.

Authors:  Neena B Haider; Nissa Mollema; Meghan Gaule; Yang Yuan; Andrew J Sachs; Arne M Nystuen; Jürgen K Naggert; Patsy M Nishina
Journal:  Exp Eye Res       Date:  2009-04-18       Impact factor: 3.467

10.  Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family.

Authors:  Pascal Escher; Peter Gouras; Raphaël Roduit; Leila Tiab; Sylvain Bolay; Tania Delarive; Shiming Chen; Chih-Cheng Tsai; Masanori Hayashi; Jana Zernant; Joanna E Merriam; Nicolas Mermod; Rando Allikmets; Francis L Munier; Daniel F Schorderet
Journal:  Hum Mutat       Date:  2009-03       Impact factor: 4.878
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