OBJECTIVE: ABCA1 controls the first step in reverse cholesterol transport. The potential associations between G1051A (R219K) and -565C/T genetic polymorphisms in the ABCA1 gene, high-density lipoprotein cholesterol (HDL-C) and subclinical cardiovascular disease in the general population remains unclear. We examined these associations in a sample of Multi-Ethnic Study of Atherosclerosis (MESA) participants. METHODS: Nine hundred and sixty-nine MESA participants were genotyped and underwent CT examinations for coronary artery calcification (CAC) and carotid ultrasound examinations for intima media thickness. Genetic association analyses were performed. RESULTS: The AA genotype was associated with a 2.4mg/dl higher HDL-C, adjusting for age, gender, race/ethnicity and clinic site (p=0.04). There was a 28% lower prevalence of CAC (p=0.002) in those with AA genotype that persisted after further adjustment for HDL-C. There were no significant associations between -565C/T genotype and HDL-C. There were trends towards a higher prevalence of CAC in those with CT (PR=1.13, p=0.08) and TT (PR=1.16, p=0.08) genotypes, compared with CC genotype. Neither G1051A nor -565C/T polymorphisms were associated with carotid intima media thickness. CONCLUSION: The AA genotype of the G1051A polymorphism is associated with slightly higher HDL-C and lower prevalence of CAC and thus may protect against subclinical cardiovascular disease. The T allele of -565 C/T polymorphism may increase risk for subclinical cardiovascular disease.
OBJECTIVE:ABCA1 controls the first step in reverse cholesterol transport. The potential associations between G1051A (R219K) and -565C/T genetic polymorphisms in the ABCA1 gene, high-density lipoprotein cholesterol (HDL-C) and subclinical cardiovascular disease in the general population remains unclear. We examined these associations in a sample of Multi-Ethnic Study of Atherosclerosis (MESA) participants. METHODS: Nine hundred and sixty-nine MESA participants were genotyped and underwent CT examinations for coronary artery calcification (CAC) and carotid ultrasound examinations for intima media thickness. Genetic association analyses were performed. RESULTS: The AA genotype was associated with a 2.4mg/dl higher HDL-C, adjusting for age, gender, race/ethnicity and clinic site (p=0.04). There was a 28% lower prevalence of CAC (p=0.002) in those with AA genotype that persisted after further adjustment for HDL-C. There were no significant associations between -565C/T genotype and HDL-C. There were trends towards a higher prevalence of CAC in those with CT (PR=1.13, p=0.08) and TT (PR=1.16, p=0.08) genotypes, compared with CC genotype. Neither G1051A nor -565C/T polymorphisms were associated with carotid intima media thickness. CONCLUSION: The AA genotype of the G1051A polymorphism is associated with slightly higher HDL-C and lower prevalence of CAC and thus may protect against subclinical cardiovascular disease. The T allele of -565 C/T polymorphism may increase risk for subclinical cardiovascular disease.
Authors: Javier Delgado-Lista; Pablo Perez-Martinez; Francisco Perez-Jimenez; Antonio Garcia-Rios; Francisco Fuentes; Carmen Marin; Purificación Gómez-Luna; Antonio Camargo; Laurence D Parnell; Jose Maria Ordovas; Jose Lopez-Miranda Journal: Arterioscler Thromb Vasc Biol Date: 2010-02-25 Impact factor: 8.311
Authors: Michael Y Tsai; Jose M Ordovas; Na Li; Robert J Straka; Naomi Q Hanson; Valerie L Arends; Donna Arnett Journal: Mol Genet Metab Date: 2010-03-06 Impact factor: 4.797
Authors: Michael McGeachie; Rachel L Badovinac Ramoni; Josyf C Mychaleckyj; Karen L Furie; Jonathan M Dreyfuss; Yongmei Liu; David Herrington; Xiuqing Guo; João A Lima; Wendy Post; Jerome I Rotter; Stephen Rich; Michèle Sale; Marco F Ramoni Journal: Circulation Date: 2009-12-15 Impact factor: 29.690
Authors: Michael Y Tsai; Na Li; A Richey Sharrett; Steven Shea; David R Jacobs; Russell Tracy; Donna Arnett; Valerie Arends; Wendy Post Journal: Clin Chem Date: 2009-01-08 Impact factor: 8.327
Authors: Michael Y Tsai; Craig Johnson; W H Linda Kao; A Richey Sharrett; Valerie L Arends; Richard Kronmal; Nancy Swords Jenny; David R Jacobs; Donna Arnett; Daniel O'Leary; Wendy Post Journal: Atherosclerosis Date: 2008-02-20 Impact factor: 5.162