Verinder Sharma1. 1. Department of Psychiatry and Obstetrics & Gynecology, University of Western Ontario and Mood Disorders Program, Regional Mental Health Care London, ON, Canada. vsharma@uwo.ca
Abstract
OBJECTIVES: This paper discusses the effect of antidepressant use on the illness course in three women who were treated for first-onset postpartum depression (PPD) following childbirth. METHODS: A report of three cases of early-onset PPD in which bipolarity manifested following antidepressant treatment. RESULTS: There was no past history of psychiatric disturbance but in each case there was a family history of bipolar (BP) disorder. Treatment with antidepressants resulted in a highly unstable illness course characterized by a mixed episode, cycle acceleration, and a postpartum psychosis. However, discontinuation of antidepressants and institution of treatment with mood stabilizers and atypical neuroleptics resulted in sustained improvement and symptom remission. CONCLUSIONS: Caution is urged in the use of antidepressants to treat early-onset PPD in women at risk for developing BP disorder due to a family history of bipolar illness.
OBJECTIVES: This paper discusses the effect of antidepressant use on the illness course in three women who were treated for first-onset postpartum depression (PPD) following childbirth. METHODS: A report of three cases of early-onset PPD in which bipolarity manifested following antidepressant treatment. RESULTS: There was no past history of psychiatric disturbance but in each case there was a family history of bipolar (BP) disorder. Treatment with antidepressants resulted in a highly unstable illness course characterized by a mixed episode, cycle acceleration, and a postpartum psychosis. However, discontinuation of antidepressants and institution of treatment with mood stabilizers and atypical neuroleptics resulted in sustained improvement and symptom remission. CONCLUSIONS: Caution is urged in the use of antidepressants to treat early-onset PPD in women at risk for developing BP disorder due to a family history of bipolar illness.