OBJECTIVE: Obesity and its complications including metabolic syndrome has been increased in children and adolescents recently. Leptin is known to play an important role in the pathogenesis of obesity. METHODS: The objective of this study was to evaluate the relationship of leptin and metabolic syndrome in obese Iranian children. A cross sectional study was carried out in 65 primary schools in Tehran. The children with waist circumferences equal or above 90th percentile for their height and age were chosen for further evaluations. 505 children aged 7-12 years participated in the study. Anthropometric variables measurements, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol and serum leptin were obtained from the study sample. RESULTS: Serum leptin levels were significantly higher in girls in comparison to the boys (with median 11.0 Vs 8.25 ng/dl; P value = 0.007). Serum level of leptin were higher in children with metabolic syndrome (median 11.3 Vs 8.9 ng/dl; P value = 0.045). However, after adjustment for sex, this association was removed. CONCLUSION: Leptin did not appear to have a major role in metabolic syndrome, even though it was strongly associated with obesity parameters. More studies evaluating the relationship between leptin and metabolic syndrome in various ethnic groups are recommended.
OBJECTIVE:Obesity and its complications including metabolic syndrome has been increased in children and adolescents recently. Leptin is known to play an important role in the pathogenesis of obesity. METHODS: The objective of this study was to evaluate the relationship of leptin and metabolic syndrome in obese Iranian children. A cross sectional study was carried out in 65 primary schools in Tehran. The children with waist circumferences equal or above 90th percentile for their height and age were chosen for further evaluations. 505 children aged 7-12 years participated in the study. Anthropometric variables measurements, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol and serum leptin were obtained from the study sample. RESULTS: Serum leptin levels were significantly higher in girls in comparison to the boys (with median 11.0 Vs 8.25 ng/dl; P value = 0.007). Serum level of leptin were higher in children with metabolic syndrome (median 11.3 Vs 8.9 ng/dl; P value = 0.045). However, after adjustment for sex, this association was removed. CONCLUSION:Leptin did not appear to have a major role in metabolic syndrome, even though it was strongly associated with obesity parameters. More studies evaluating the relationship between leptin and metabolic syndrome in various ethnic groups are recommended.
Authors: M Shimabukuro; K Koyama; G Chen; M Y Wang; F Trieu; Y Lee; C B Newgard; R H Unger Journal: Proc Natl Acad Sci U S A Date: 1997-04-29 Impact factor: 11.205
Authors: F Leyva; I F Godsland; M Ghatei; A J Proudler; S Aldis; C Walton; S Bloom; J C Stevenson Journal: Arterioscler Thromb Vasc Biol Date: 1998-06 Impact factor: 8.311
Authors: Srinivasa Nageswara Rao; G Prema Gurumurthy; Priya Gururajan; Sarasa Barathi Arumugam; V Kirthivasan; K M Cherian Journal: Indian J Pediatr Date: 2010-04-17 Impact factor: 1.967
Authors: G Srinivasa Nageswara Rao; Gurumurthy Prema; Gururajan Priya; Sarasa Barathi Arumugam; V Kirthivasan; R Saibabu; K M Cherian Journal: Indian J Clin Biochem Date: 2010-08-25