OBJECTIVE: Individuals with autism spectrum disorders typically have normal visuospatial abilities but impaired executive functioning, particularly in abilities related to working memory and attention. The aim of this study was to elucidate the functioning of frontoparietal networks underlying spatial working memory processes during mental rotation in persons with autism spectrum disorders. METHOD: Seven adolescent males with normal IQ with an autism spectrum disorder and nine age- and IQ-matched male comparison subjects underwent functional magnetic resonance imaging scans while performing a mental rotation task. RESULTS: The autism spectrum disorders group showed less activation in lateral and medial premotor cortex, dorsolateral prefrontal cortex, anterior cingulate gyrus, and caudate nucleus. CONCLUSIONS: The finding of less activation in prefrontal regions but not in parietal regions supports a model of dysfunction of frontostriatal networks in autism spectrum disorders.
OBJECTIVE: Individuals with autism spectrum disorders typically have normal visuospatial abilities but impaired executive functioning, particularly in abilities related to working memory and attention. The aim of this study was to elucidate the functioning of frontoparietal networks underlying spatial working memory processes during mental rotation in persons with autism spectrum disorders. METHOD: Seven adolescent males with normal IQ with an autism spectrum disorder and nine age- and IQ-matched male comparison subjects underwent functional magnetic resonance imaging scans while performing a mental rotation task. RESULTS: The autism spectrum disorders group showed less activation in lateral and medial premotor cortex, dorsolateral prefrontal cortex, anterior cingulate gyrus, and caudate nucleus. CONCLUSIONS: The finding of less activation in prefrontal regions but not in parietal regions supports a model of dysfunction of frontostriatal networks in autism spectrum disorders.
Authors: Laura Pina-Camacho; Sonia Villero; David Fraguas; Leticia Boada; Joost Janssen; Francisco J Navas-Sánchez; Maria Mayoral; Cloe Llorente; Celso Arango; Mara Parellada Journal: J Autism Dev Disord Date: 2012-07
Authors: Ryan R Green; Erin D Bigler; Alyson Froehlich; Molly B D Prigge; Brittany G Travers; Annahir N Cariello; Jeffrey S Anderson; Brandon A Zielinski; Andrew Alexander; Nicholas Lange; Janet E Lainhart Journal: Child Neuropsychol Date: 2015-08-21 Impact factor: 2.500
Authors: Nanda N J Rommelse; Alejandro Arias-Vásquez; Marieke E Altink; Cathelijne J M Buschgens; Ellen Fliers; Philip Asherson; Stephen V Faraone; Jan K Buitelaar; Joseph A Sergeant; Jaap Oosterlaan; Barbara Franke Journal: Am J Hum Genet Date: 2008-07 Impact factor: 11.025
Authors: Charline Urbain; Vanessa M Vogan; Annette X Ye; Elizabeth W Pang; Sam M Doesburg; Margot J Taylor Journal: Hum Brain Mapp Date: 2015-10-20 Impact factor: 5.038
Authors: Lauren Kenworthy; Benjamin E Yerys; Laura Gutermuth Anthony; Gregory L Wallace Journal: Neuropsychol Rev Date: 2008-10-28 Impact factor: 7.444