| Literature DB >> 16877258 |
Kanako Wakabayashi1, Ai Tamura, Hikaru Saito, Yuko Onishi, Toshihisa Ishikawa.
Abstract
Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is regarded as a member of the phase III system of xenobiotic metabolism. This efflux pump is suggested to be responsible for protecting the body from toxic xenobiotics and for removing toxic metabolites. The aim of this review article is to address new aspects of ABCG2 related to redox biology, namely the posttranslational modification (intra- and intermolecular disulfide bond formation) of ABCG2 protein and the transport of porphyrin and chlorophyll metabolites, as well as the high-speed screening and QSAR analysis method to evaluate ABCG2-drug interactions.Entities:
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Year: 2006 PMID： 16877258 DOI： 10.1080/03602530600727947
Source DB: PubMed Journal: Drug Metab Rev ISSN： 0360-2532 Impact factor: 4.518