| Literature DB >> 16876410 |
Jae Yeol Lee1, Seong Jun Park, Sung Jun Park, Min Joo Lee, Hyewhon Rhim, Seon Hee Seo, Ki-Sun Kim.
Abstract
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.Entities:
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Year: 2006 PMID： 16876410 DOI： 10.1016/j.bmcl.2006.07.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823