Literature DB >> 1687377

Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices.

S J Annels1, Y Ellis, J A Davies.   

Abstract

The non-opioid antitussive drugs, dextromethorphan, caramiphen and carbetapentane, are also anticonvulsant. The effects of these antitussives on potassium-stimulated release of endogenous amino acids from rabbit hippocampal slices was tested. All 3 drugs significantly reduced the release of glutamate, with carbetapentane being the most potent (IC50 approximately 40 microM). We suggest that the anticonvulsant action may be due to their ability to decrease glutamate release.

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Year:  1991        PMID： 1687377     DOI： 10.1016/0006-8993(91)91474-f

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Neuroprotective efficacy of caramiphen against soman and mechanisms of its action.

Authors:  T H Figueiredo; V Aroniadou-Anderjaska; F Qashu; J P Apland; V Pidoplichko; D Stevens; T M Ferrara; M F M Braga
Journal:  Br J Pharmacol       Date:  2011-11       Impact factor: 8.739

2.  Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.

Authors:  James P Apland; Vassiliki Aroniadou-Anderjaska; Taiza H Figueiredo; Volodymyr I Pidoplichko; Katia Rossetti; Maria F M Braga
Journal:  J Pharmacol Exp Ther       Date:  2018-02-21       Impact factor: 4.030

3.  The effects of sigma ligands on the release of glutamate from rat striatal slices.

Authors:  Y Ellis; J A Davies
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-08       Impact factor: 3.000

4.  Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones.

Authors:  J Church; E J Fletcher
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739

5.  Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions.

Authors:  J Church; E J Fletcher; K Baxter; J F MacDonald
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739

6.  Lithium stimulates glutamate "release" and inositol 1,4,5-trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices.

Authors:  J F Dixon; G V Los; L E Hokin
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205

7.  Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats.

Authors:  James P Apland; Vassiliki Aroniadou-Anderjaska; Taiza H Figueiredo; Marcio De Araujo Furtado; Maria F M Braga
Journal:  Neurotox Res       Date:  2018-04-30       Impact factor: 3.911
  7 in total

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