| Literature DB >> 16873667 |
Noelia V Weisstaub1, Mingming Zhou, Alena Lira, Evelyn Lambe, Javier González-Maeso, Jean-Pierre Hornung, Etienne Sibille, Mark Underwood, Shigeyoshi Itohara, William T Dauer, Mark S Ansorge, Emanuela Morelli, J John Mann, Miklos Toth, George Aghajanian, Stuart C Sealfon, René Hen, Jay A Gingrich.
Abstract
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.Entities:
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Year: 2006 PMID： 16873667 DOI： 10.1126/science.1123432
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728