BACKGROUND: A few studies have analyzed the role of lifetime anthropometric measures on laryngeal cancer risk. PATIENT AND METHODS: This relation was investigated using a multicentre case-control study from Italy, conducted between 1992 and 2000, and including 460 incident, histologically confirmed laryngeal cancer cases, and 1088 controls admitted to the same network of hospitals as cases for acute, non neoplastic condition. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were obtained from multiple logistic regression, including terms for major confounding factors, such as physical activity and energy intake. RESULTS: An inverse association with laryngeal cancer risk was found for body mass index (BMI) in both sexes (OR for the lowest compared to the highest quintile was 1.47, 95% CI 0.93-2.33 in men and 8.11, 95% CI 1.38-47.66 in women) and for BMI at age 50 years (OR=1.65, 95% CI 0.88-3.11) in men and 7.84, 95% CI 0.69-88.58 in women). An inverse association was also observed with waist-to-hip ratio (WHR) at diagnosis in men only (OR=4.56, 95% CI 2.62-7.95 for the lowest compared to the highest quintile). CONCLUSIONS: This study supports the existence of a relation between leanness and laryngeal cancer risk. In particular, men with less abdominal fat (characterized by a lower WHR) had an increased risk of laryngeal cancer.
BACKGROUND: A few studies have analyzed the role of lifetime anthropometric measures on laryngeal cancer risk. PATIENT AND METHODS: This relation was investigated using a multicentre case-control study from Italy, conducted between 1992 and 2000, and including 460 incident, histologically confirmed laryngeal cancer cases, and 1088 controls admitted to the same network of hospitals as cases for acute, non neoplastic condition. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were obtained from multiple logistic regression, including terms for major confounding factors, such as physical activity and energy intake. RESULTS: An inverse association with laryngeal cancer risk was found for body mass index (BMI) in both sexes (OR for the lowest compared to the highest quintile was 1.47, 95% CI 0.93-2.33 in men and 8.11, 95% CI 1.38-47.66 in women) and for BMI at age 50 years (OR=1.65, 95% CI 0.88-3.11) in men and 7.84, 95% CI 0.69-88.58 in women). An inverse association was also observed with waist-to-hip ratio (WHR) at diagnosis in men only (OR=4.56, 95% CI 2.62-7.95 for the lowest compared to the highest quintile). CONCLUSIONS: This study supports the existence of a relation between leanness and laryngeal cancer risk. In particular, men with less abdominal fat (characterized by a lower WHR) had an increased risk of laryngeal cancer.
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Authors: Jay H Lubin; Joshua Muscat; Mia M Gaudet; Andrew F Olshan; Maria Paula Curado; Luigino Dal Maso; Victor Wünsch-Filho; Erich M Sturgis; Neonilia Szeszenia-Dabrowska; Xavier Castellsague; Zuo-Feng Zhang; Elaine Smith; Leticia Fernandez; Elena Matos; Silvia Franceschi; Eleonora Fabianova; Peter Rudnai; Mark P Purdue; Dana Mates; Qingyi Wei; Rolando Herrero; Karl Kelsey; Hal Morgenstern; Oxana Shangina; Sergio Koifman; Jolanta Lissowska; Fabio Levi; Alexander W Daudt; Jose Eluf Neto; Chu Chen; Philip Lazarus; Deborah M Winn; Stephen M Schwartz; Paolo Boffetta; Paul Brennan; Ana Menezes; Carlo La Vecchia; Michael McClean; Renato Talamini; Thangarajan Rajkumar; Richard B Hayes; Mia Hashibe Journal: Cancer Causes Control Date: 2011-07-09 Impact factor: 2.506
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