Literature DB >> 16873422

Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner.

Makoto Ohmoto1, Ichiro Matsumoto, Takumi Misaka, Keiko Abe.   

Abstract

Two voltage-dependent potassium channels, KCNQ1 and KCNH2, are expressed in the taste buds and were identified as strong candidates involved in the repolarization of taste receptor cells expressing phospholipase C-beta2 and TRPM5 (beta2/M5-TRCs). In cell type-specific expression, KCNQ1 was expressed in most taste bud cells, including beta2/M5-TRCs, whereas KCNH2 was expressed in a subset of beta2/M5-TRCs with no correlation with their taste modality, such as sweet or bitter taste reception. Expression of KCNH2 was restricted to young beta2/M5-TRCs. These results suggest that taste bud cells other than beta2/M5-TRCs are depolarized by some stimuli and also that beta2/M5-TRCs have cell age-dependent molecular mechanisms of repolarization.

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Year:  2006        PMID： 16873422     DOI： 10.1093/chemse/bjl016

Source DB:  PubMed          Journal:  Chem Senses        ISSN： 0379-864X            Impact factor:   3.160


  14 in total

1.  Skn-1a (Pou2f3) specifies taste receptor cell lineage.

Authors:  Ichiro Matsumoto; Makoto Ohmoto; Masataka Narukawa; Yoshihiro Yoshihara; Keiko Abe
Journal:  Nat Neurosci       Date:  2011-05-15       Impact factor: 24.884

2.  Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses.

Authors:  Joto Yoshimoto; Shinji Okada; Mikiya Kishi; Takumi Misaka
Journal:  J Histochem Cytochem       Date:  2015-12-30       Impact factor: 2.479

3.  Genetic Lineage Tracing in Taste Tissues Using Sox2-CreERT2 Strain.

Authors:  Makoto Ohmoto; Wenwen Ren; Yugo Nishiguchi; Junji Hirota; Peihua Jiang; Ichiro Matsumoto
Journal:  Chem Senses       Date:  2017-09-01       Impact factor: 3.160

4.  Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish.

Authors:  Makoto Ohmoto; Shinji Okada; Shugo Nakamura; Keiko Abe; Ichiro Matsumoto
Journal:  J Comp Neurol       Date:  2011-06-01       Impact factor: 3.215

5.  Action potentials and ion conductances in wild-type and CALHM1-knockout type II taste cells.

Authors:  Zhongming Ma; Wint Thu Saung; J Kevin Foskett
Journal:  J Neurophysiol       Date:  2017-02-15       Impact factor: 2.714

6.  Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds.

Authors:  Gennady Dvoryanchikov; Michael S Sinclair; Isabel Perea-Martinez; Tong Wang; Nirupa Chaudhari
Journal:  J Comp Neurol       Date:  2009-11-01       Impact factor: 3.215

7.  Expression of Eya1 in mouse taste buds.

Authors:  Makoto Ohmoto; Satsuki Kitamoto; Junji Hirota
Journal:  Cell Tissue Res       Date:  2020-11-26       Impact factor: 5.249

8.  Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences.

Authors:  Hong Wang; Naoko Iguchi; Qi Rong; Minliang Zhou; Martina Ogunkorode; Masashi Inoue; Edmund A Pribitkin; Alexander A Bachmanov; Robert F Margolskee; Karl Pfeifer; Liquan Huang
Journal:  J Comp Neurol       Date:  2009-01-20       Impact factor: 3.215

9.  Voltage-gated sodium channels in taste bud cells.

Authors:  Na Gao; Min Lu; Fernando Echeverri; Bianca Laita; Dalia Kalabat; Mark E Williams; Peter Hevezi; Albert Zlotnik; Bryan D Moyer
Journal:  BMC Neurosci       Date:  2009-03-12       Impact factor: 3.288

10.  CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.

Authors:  Akiyuki Taruno; Valérie Vingtdeux; Makoto Ohmoto; Zhongming Ma; Gennady Dvoryanchikov; Ang Li; Leslie Adrien; Haitian Zhao; Sze Leung; Maria Abernethy; Jeremy Koppel; Peter Davies; Mortimer M Civan; Nirupa Chaudhari; Ichiro Matsumoto; Göran Hellekant; Michael G Tordoff; Philippe Marambaud; J Kevin Foskett
Journal:  Nature       Date:  2013-03-06       Impact factor: 49.962
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