Literature DB >> 16873270

Viral determinants of integration site preferences of simian immunodeficiency virus-based vectors.

Hella Monse1, Stephanie Laufs, Seraphin Kuate, W Jens Zeller, Stefan Fruehauf, Klaus Uberla.   

Abstract

Preferential integration into transcriptionally active regions of genomes has been observed for retroviral vectors based on gamma-retroviruses and lentiviruses. However, differences in the integration site preferences were detected, which might be explained by differences in viral components of the preintegration complexes. Viral determinants of integration site preferences have not been defined. Therefore, integration sites of simian immunodeficiency virus (SIV)-based vectors produced in the absence of accessory genes or lacking promoter and enhancer elements were compared. Similar integration patterns for the different SIV vectors indicate that vif, vpr, vpx, nef, env, and promoter or enhancer elements are not required for preferential integration of SIV into transcriptionally active regions of genomes.

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Year:  2006        PMID： 16873270      PMCID： PMC1563816          DOI： 10.1128/JVI.00373-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Rev-independent expression of synthetic gag-pol genes of human immunodeficiency virus type 1 and simian immunodeficiency virus: implications for the safety of lentiviral vectors.

Authors:  R Wagner; M Graf; K Bieler; H Wolf; T Grunwald; P Foley; K Uberla
Journal:  Hum Gene Ther       Date:  2000-11-20       Impact factor: 5.695

2.  HIV-1 integration in the human genome favors active genes and local hotspots.

Authors:  Astrid R W Schröder; Paul Shinn; Huaming Chen; Charles Berry; Joseph R Ecker; Frederic Bushman
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

3.  HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.

Authors:  Peter Cherepanov; Goedele Maertens; Paul Proost; Bart Devreese; Jozef Van Beeumen; Yves Engelborghs; Erik De Clercq; Zeger Debyser
Journal:  J Biol Chem       Date:  2002-10-28       Impact factor: 5.157

4.  The human transcriptome map: clustering of highly expressed genes in chromosomal domains.

Authors:  H Caron; B van Schaik ; M van der Mee ; F Baas; G Riggins; P van Sluis ; M C Hermus; R van Asperen ; K Boon; P A Voûte; S Heisterkamp; A van Kampen ; R Versteeg
Journal:  Science       Date:  2001-02-16       Impact factor: 47.728

5.  A role for LEDGF/p75 in targeting HIV DNA integration.

Authors:  Angela Ciuffi; Manuel Llano; Eric Poeschla; Christian Hoffmann; Jeremy Leipzig; Paul Shinn; Joseph R Ecker; Frederic Bushman
Journal:  Nat Med       Date:  2005-11-27       Impact factor: 53.440

6.  Development of a self-inactivating, minimal lentivirus vector based on simian immunodeficiency virus.

Authors:  T Schnell; P Foley; M Wirth; J Münch; K Uberla
Journal:  Hum Gene Ther       Date:  2000-02-10       Impact factor: 5.695

7.  The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation.

Authors:  A Jordan; P Defechereux; E Verdin
Journal:  EMBO J       Date:  2001-04-02       Impact factor: 11.598

8.  Reducing mobilization of simian immunodeficiency virus based vectors by primer complementation.

Authors:  Thomas Grunwald; Finn Skou Pedersen; Ralf Wagner; Klaus Uberla
Journal:  J Gene Med       Date:  2004-02       Impact factor: 4.565

9.  Transcription start regions in the human genome are favored targets for MLV integration.

Authors:  Xiaolin Wu; Yuan Li; Bruce Crise; Shawn M Burgess
Journal:  Science       Date:  2003-06-13       Impact factor: 47.728

10.  Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.

Authors:  Rick S Mitchell; Brett F Beitzel; Astrid R W Schroder; Paul Shinn; Huaming Chen; Charles C Berry; Joseph R Ecker; Frederic D Bushman
Journal:  PLoS Biol       Date:  2004-08-17       Impact factor: 8.029
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  5 in total

Review 1.  Integration site selection by retroviral vectors: molecular mechanism and clinical consequences.

Authors:  René Daniel; Johanna A Smith
Journal:  Hum Gene Ther       Date:  2008-06       Impact factor: 5.695

Review 2.  Sites of retroviral DNA integration: From basic research to clinical applications.

Authors:  Erik Serrao; Alan N Engelman
Journal:  Crit Rev Biochem Mol Biol       Date:  2015-10-28       Impact factor: 8.250

3.  Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation.

Authors:  Sabine Brandt; Maik Blissenbach; Bastian Grewe; Rebecca Konietzny; Thomas Grunwald; Klaus Uberla
Journal:  PLoS Pathog       Date:  2007-04       Impact factor: 6.823

4.  Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes.

Authors:  Mauro Pistello; Laura Vannucci; Alessia Ravani; Francesca Bonci; Flavia Chiuppesi; Barbara del Santo; Giulia Freer; Mauro Bendinelli
Journal:  Genet Vaccines Ther       Date:  2007-09-19

5.  Refinement of lentiviral vector for improved RNA processing and reduced rates of self inactivation repair.

Authors:  Rachel M Koldej; Donald S Anson
Journal:  BMC Biotechnol       Date:  2009-10-07       Impact factor: 2.563
  5 in total

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