Literature DB >> 16872130

Diterpenes from Leucas aspera inhibiting prostaglandin-induced contractions.

Samir Kumar Sadhu1, Emi Okuyama, Haruhiro Fujimoto, Masami Ishibashi.   

Abstract

Investigation of the inhibitory fraction of Leucas aspera on prostaglandin-induced contraction in guinea pig ileum provided four new diterpenes, leucasperones A (1) and B (2) and leucasperols A (3) and B (4), and three new isopimarane glycosides, leucasperosides A, B, and C (5-7), together with the known compounds asperphenamate, maslinic acid, (-)-isololiolide, and linifolioside. The structures of the compounds were determined by detailed spectroscopic analysis. The configurations of 1 and 2 and the acetylated derivatives of 3 and 4 were determined by differential NOE analysis and CD data. Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions.

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Year:  2006        PMID： 16872130     DOI： 10.1021/np058118m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

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Journal:  J Nat Med       Date:  2010-07-06       Impact factor: 2.343

2.  Antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract.

Authors:  Md Atiar Rahman; Md Saiful Islam
Journal:  Asian Pac J Trop Biomed       Date:  2013-04

3.  Studies on larvicidal and pupicidal activity of Leucas aspera Willd. (Lamiaceae) and bacterial insecticide, Bacillus sphaericus, against malarial vector, Anopheles stephensi Liston. (Diptera: Culicidae).

Authors:  Kalimuthu Kovendan; Kadarkarai Murugan; Savariar Vincent; Donald R Barnard
Journal:  Parasitol Res       Date:  2011-05-31       Impact factor: 2.289

4.  Antioxidant and antibacterial activity of different parts of Leucas aspera.

Authors:  Ai Lan Chew; Jeyanthi James Antony Jessica; Sreenivasan Sasidharan
Journal:  Asian Pac J Trop Biomed       Date:  2012-03

5.  A review: Ethnobotanical survey of genus Leucas.

Authors:  Surya Narayan Das; Varanasi Jaganath Patro; Subas Chandra Dinda
Journal:  Pharmacogn Rev       Date:  2012-07

6.  Laboratory and field evaluation of medicinal plant extracts against filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae).

Authors:  Kalimuthu Kovendan; Kadarkarai Murugan; Chellasamy Panneerselvam; Palanisamy Mahesh Kumar; Duraisamy Amerasan; Jayapal Subramaniam; Savariar Vincent; Donald R Barnard
Journal:  Parasitol Res       Date:  2011-12-07       Impact factor: 2.383

7.  Leucas aspera: A review.

Authors:  M S Prajapati; J B Patel; K Modi; M B Shah
Journal:  Pharmacogn Rev       Date:  2010-01

8.  Functional characterization and expression profile of microsomal FAD2 and FAD3 genes involved in linoleic and α-linolenic acid production in Leucas cephalotes.

Authors:  Ashish Kumar Choudhary; Girish Mishra
Journal:  Physiol Mol Biol Plants       Date:  2021-06-07

9.  Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine.

Authors:  Ramzi A Mothana; Nawal M Al-Musayeib; Mohamed F Al-Ajmi; Paul Cos; Louis Maes
Journal:  Evid Based Complement Alternat Med       Date:  2014-05-21       Impact factor: 2.629

Review 10.  Authentication of the botanical origin of Western herbal products using Cimicifuga and Vitex products as examples.

Authors:  Sayaka Masada
Journal:  J Nat Med       Date:  2016-05-17       Impact factor: 2.343
  10 in total

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