Literature DB >> 16871601

Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease.

Philippe Compain1, Olivier R Martin, Charlotte Boucheron, Guillaume Godin, Liang Yu, Kyoko Ikeda, Naoki Asano.   

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Year:  2006        PMID： 16871601     DOI： 10.1002/cbic.200600217

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  24 in total

1.  Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.

Authors:  Samarjit Patnaik; Wei Zheng; Jae H Choi; Omid Motabar; Noel Southall; Wendy Westbroek; Wendy A Lea; Arash Velayati; Ehud Goldin; Ellen Sidransky; William Leister; Juan J Marugan
Journal:  J Med Chem       Date:  2012-06-08       Impact factor: 7.446

2.  Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.

Authors:  Wei Zheng; Janak Padia; Daniel J Urban; Ajit Jadhav; Ozlem Goker-Alpan; Anton Simeonov; Ehud Goldin; Douglas Auld; Mary E LaMarca; James Inglese; Christopher P Austin; Ellen Sidransky
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-01       Impact factor: 11.205

3.  Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.

Authors:  Raquel L Lieberman; J Alejandro D'aquino; Dagmar Ringe; Gregory A Petsko
Journal:  Biochemistry       Date:  2009-06-09       Impact factor: 3.162

Review 4.  Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis.

Authors:  Susan L Lindquist; Jeffery W Kelly
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-12-01       Impact factor: 10.005

5.  Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.

Authors:  Ethan D Goddard-Borger; Michael B Tropak; Sayuri Yonekawa; Christina Tysoe; Don J Mahuran; Stephen G Withers
Journal:  J Med Chem       Date:  2012-03-06       Impact factor: 7.446

6.  Non-iminosugar glucocerebrosidase small molecule chaperones.

Authors:  Juan Jose Marugan; Wenwei Huang; Omid Motabar; Wei Zheng; Jingbo Xiao; Samarjit Patnaik; Noel Southall; Wendy Westbroek; Wendy A Lea; Anton Simeonov; Ehud Goldin; Maria A Debernardi; Ellen Sidransky
Journal:  Medchemcomm       Date:  2011-10-24       Impact factor: 3.597

7.  The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.

Authors:  Ana Trapero; Amadeu Llebaria
Journal:  ACS Med Chem Lett       Date:  2011-05-18       Impact factor: 4.345

8.  Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Authors:  Juan J Marugan; Wei Zheng; Omid Motabar; Noel Southall; Ehud Goldin; Wendy Westbroek; Barbara K Stubblefield; Ellen Sidransky; Ronald A Aungst; Wendy A Lea; Anton Simeonov; William Leister; Christopher P Austin
Journal:  J Med Chem       Date:  2011-01-20       Impact factor: 7.446

Review 9.  Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.

Authors:  Olive Jung; Samarjit Patnaik; Juan Marugan; Ellen Sidransky; Wendy Westbroek
Journal:  Expert Rev Proteomics       Date:  2016-04-21       Impact factor: 3.940

10.  Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.

Authors:  Michael B Tropak; Gregory J Kornhaber; Brigitte A Rigat; Gustavo H Maegawa; Justin D Buttner; Jan E Blanchard; Cecilia Murphy; Steven J Tuske; Stephen J Coales; Yoshitomo Hamuro; Eric D Brown; Don J Mahuran
Journal:  Chembiochem       Date:  2008-11-03       Impact factor: 3.164
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