Literature DB >> 16871558

Pattern recognition receptors: a contemporary view on liver diseases.

Gyongyi Szabo1, Angela Dolganiuc, Pranoti Mandrekar.   

Abstract

Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16871558     DOI： 10.1002/hep.21308

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


  72 in total

1.  Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.

Authors:  Jan Petrasek; Angela Dolganiuc; Timea Csak; Bharath Nath; Istvan Hritz; Karen Kodys; Donna Catalano; Evelyn Kurt-Jones; Pranoti Mandrekar; Gyongyi Szabo
Journal:  Hepatology       Date:  2011-01-10       Impact factor: 17.425

2.  Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.

Authors:  Kouichi Miura; Yuzo Kodama; Sayaka Inokuchi; Bernd Schnabl; Tomonori Aoyama; Hirohide Ohnishi; Jerrold M Olefsky; David A Brenner; Ekihiro Seki
Journal:  Gastroenterology       Date:  2010-03-27       Impact factor: 22.682

Review 3.  Pathophysiology of portal hypertension and its clinical links.

Authors:  Yeon Seok Seo; Vijay H Shah
Journal:  J Clin Exp Hepatol       Date:  2011-11-09

Review 4.  Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies.

Authors:  Jing-Ting Li; Zhang-Xiu Liao; Jie Ping; Dan Xu; Hui Wang
Journal:  J Gastroenterol       Date:  2008-07-04       Impact factor: 7.527

5.  The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.

Authors:  Istvan Hritz; Pranoti Mandrekar; Arumugam Velayudham; Donna Catalano; Angela Dolganiuc; Karen Kodys; Evelyn Kurt-Jones; Gyongyi Szabo
Journal:  Hepatology       Date:  2008-10       Impact factor: 17.425

6.  Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.

Authors:  Romina Fiorotto; Roberto Scirpo; Michael Trauner; Luca Fabris; Rafaz Hoque; Carlo Spirli; Mario Strazzabosco
Journal:  Gastroenterology       Date:  2011-06-26       Impact factor: 22.682

Review 7.  Role of innate immunity in the development of hepatocellular carcinoma.

Authors:  Rajagopal N Aravalli
Journal:  World J Gastroenterol       Date:  2013-11-21       Impact factor: 5.742

8.  Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.

Authors:  Andressa Franca; Antonio Carlos Melo Lima Filho; Mateus T Guerra; Jittima Weerachayaphorn; Marcone Loiola Dos Santos; Basile Njei; Marie Robert; Cristiano Xavier Lima; Paula Vieira Teixeira Vidigal; Jesus M Banales; Meenakshisundaram Ananthanarayanam; M Fatima Leite; Michael H Nathanson
Journal:  Hepatology       Date:  2018-12-31       Impact factor: 17.425

Review 9.  Kupffer cells in non-alcoholic fatty liver disease: the emerging view.

Authors:  György Baffy
Journal:  J Hepatol       Date:  2009-03-31       Impact factor: 25.083

Review 10.  A recent perspective on alcohol, immunity, and host defense.

Authors:  Gyongyi Szabo; Pranoti Mandrekar
Journal:  Alcohol Clin Exp Res       Date:  2008-12-02       Impact factor: 3.455
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.