Literature DB >> 1687122

Thyrotropin-releasing hormone excites submucous neurons in guinea-pig ileum.

D H Zafirov1, H J Cooke, J D Wood.   

Abstract

Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.

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Year:  1991        PMID： 1687122     DOI： 10.1016/0014-2999(91)90843-f

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Synaptic transmission at functionally identified synapses in the enteric nervous system: roles for both ionotropic and metabotropic receptors.

Authors:  R M Gwynne; J C Bornstein
Journal:  Curr Neuropharmacol       Date:  2007-03       Impact factor: 7.363

2.  Efficacy of leuprolide in treatment of the irritable bowel syndrome.

Authors:  J D Wood
Journal:  Dig Dis Sci       Date:  1994-06       Impact factor: 3.199

3.  Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system.

Authors:  Sumei Liu; Mei-Hua Qu; Wei Ren; Hong-Zhen Hu; Na Gao; Guo-Du Wang; Xi-Yu Wang; Guijun Fei; Fei Zuo; Yun Xia; Jackie D Wood
Journal:  J Comp Neurol       Date:  2008-12-20       Impact factor: 3.215

Review 4.  The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?

Authors:  Jean-Louis Charli; Adair Rodríguez-Rodríguez; Karina Hernández-Ortega; Antonieta Cote-Vélez; Rosa María Uribe; Lorraine Jaimes-Hoy; Patricia Joseph-Bravo
Journal:  Front Pharmacol       Date:  2020-05-08       Impact factor: 5.810
  4 in total

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