Literature DB >> 16870784

Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides.

Yvonne Adams1, Craig Freeman, Reinhard Schwartz-Albiez, Vito Ferro, Christopher R Parish, Katherine T Andrews.   

Abstract

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 microM) and demonstrated modest adhesion inhibition to cell surface CSA.

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Year:  2006        PMID： 16870784      PMCID： PMC1538674          DOI： 10.1128/AAC.00313-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

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5.  Cerebral malaria in children. Comparative study between heparin, dexamethasone and placebo.

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Authors:  M Fried; P E Duffy
Journal:  Science       Date:  1996-06-07       Impact factor: 47.728

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  8 in total

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