| Literature DB >> 16870425 |
MinKyun Na1, JunPil Jang, Byung Sun Min, Sang Jun Lee, Myung Sun Lee, Bo Yeon Kim, Won Keun Oh, Jong Seog Ahn.
Abstract
Fatty acid synthase (FAS) is emerging as a potential therapeutic target to treat cancer and obesity. Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae), using an in vitro FAS inhibitory assay, resulted in the isolation of a series of acylphloroglucinols, as the active principles. The isolates 1-10 inhibited FAS with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM. The results of the present study indicate that the acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors.Entities:
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Year: 2006 PMID： 16870425 DOI： 10.1016/j.bmcl.2006.07.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823