Literature DB >> 16870137

BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.

Zekun Guo1, Wenwen Tang, Jian Yuan, Xinya Chen, Bo Wan, Xiuting Gu, Kuntian Luo, Yingli Wang, Long Yu.   

Abstract

Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA.

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Year:  2006        PMID： 16870137     DOI： 10.1016/j.bbrc.2006.06.178

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

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2.  Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.

Authors:  Nicola J Bright; David Carling; Claire Thornton
Journal:  J Biol Chem       Date:  2008-03-13       Impact factor: 5.157

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Authors:  Jia Nie; Xiao Han; Yuguang Shi
Journal:  Cell Cycle       Date:  2013-09-18       Impact factor: 4.534

4.  SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.

Authors:  Jia Nie; Brendan N Lilley; Y Albert Pan; Omar Faruque; Xiaolei Liu; Weiping Zhang; Joshua R Sanes; Xiao Han; Yuguang Shi
Journal:  Mol Cell Biol       Date:  2013-04-29       Impact factor: 4.272

5.  SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells.

Authors:  Jia Nie; Chao Sun; Zhijie Chang; Nicolas Musi; Yuguang Shi
Journal:  Endocrinology       Date:  2018-08-01       Impact factor: 4.736

6.  Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites.

Authors:  Neil F W Saunders; Ross I Brinkworth; Thomas Huber; Bruce E Kemp; Bostjan Kobe
Journal:  BMC Bioinformatics       Date:  2008-05-26       Impact factor: 3.169

7.  Polarized activities of AMPK and BRSK in primary hippocampal neurons.

Authors:  Vedangi Sample; Santosh Ramamurthy; Kirill Gorshkov; Gabriele V Ronnett; Jin Zhang
Journal:  Mol Biol Cell       Date:  2015-03-18       Impact factor: 4.138

8.  Using bacteria to determine protein kinase specificity and predict target substrates.

Authors:  Michael F Chou; Sladjana Prisic; Joshua M Lubner; George M Church; Robert N Husson; Daniel Schwartz
Journal:  PLoS One       Date:  2012-12-26       Impact factor: 3.240
  8 in total

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