Literature DB >> 16869659

An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C2 core symmetry. Total synthesis of asimicin and a C32 analogue.

James A Marshall1, Jesse J Sabatini.   

Abstract

[reaction: see text] A synthesis of the Annonaceous acetogenin asimicin and a side-chain analogue has been achieved by a highly convergent route in which Grubbs cross-metathesis plays a key role.

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Year:  2006        PMID： 16869659     DOI： 10.1021/ol061352z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.

Authors:  Subhash C Sinha; Zhiyong Chen; Zheng-Zheng Huang; Eiko Nakamaru-Ogiso; Halina Pietraszkiewicz; Matthew Edelstein; Frederick Valeriote
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

2.  Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin.

Authors:  Feng Wang; Akira Kawamura; David R Mootoo
Journal:  Bioorg Med Chem       Date:  2008-08-19       Impact factor: 3.641

3.  Synthesis of fused-ring and attached-ring bis-tetrahydrofurans via Pd-catalyzed carboetherification.

Authors:  Amanda F Ward; John P Wolfe
Journal:  Org Lett       Date:  2009-05-21       Impact factor: 6.005

4.  Recent progress on the total synthesis of acetogenins from Annonaceae.

Authors:  Nianguang Li; Zhihao Shi; Yuping Tang; Jianwei Chen; Xiang Li
Journal:  Beilstein J Org Chem       Date:  2008-12-05       Impact factor: 2.883
  4 in total

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