Literature DB >> 16869646

Reaction of N-monosubstituted hydrazones with nitroolefins: a novel regioselective pyrazole synthesis.

Xiaohu Deng1, Neelakandha S Mani.   

Abstract

A novel regioselective synthesis of substituted pyrazoles from N-monosubstituted hydrazones and nitroolefins is described. The reaction is performed in a one-pot manner and the yields range from moderate to excellent. A key nitropyrazolidine intermediate is characterized and a plausible mechanism is proposed.

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Year:  2006        PMID： 16869646     DOI： 10.1021/ol061226v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors:  Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

2.  A novel pseudo six-component synthesis of functionalized pyrazoles in ethanol by cascade reaction.

Authors:  Atieh Rezvanian; Maedeh Babashah; Maryam Anafcheh
Journal:  Mol Divers       Date:  2019-01-11       Impact factor: 2.943

3.  One Pot Spiropyrazoline Synthesis via Intramolecular Cyclization/Methylation.

Authors:  Sureshbabu Dadiboyena; Ashton T Hamme
Journal:  Tetrahedron Lett       Date:  2011-05-18       Impact factor: 2.415

4.  Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates.

Authors:  Sureshbabu Dadiboyena; Edward J Valente; Ashton T Hamme
Journal:  Tetrahedron Lett       Date:  2010-03-03       Impact factor: 2.415

5.  A Novel Synthesis of 1,3,5-Trisubstituted Pyrazoles through a Spiro-pyrazoline Intermediate via a Tandem 1,3-Dipolar Cycloaddition/Elimination.

Authors:  Sureshbabu Dadiboyena; Edward J Valente; Ashton T Hamme
Journal:  Tetrahedron Lett       Date:  2009-01-21       Impact factor: 2.415

6.  Multicomponent Pyrazole Synthesis from Alkynes, Nitriles, and Titanium Imido Complexes via Oxidatively Induced N-N Bond Coupling.

Authors:  Adam J Pearce; Robin P Harkins; Benjamin R Reiner; Alexander C Wotal; Rachel J Dunscomb; Ian A Tonks
Journal:  J Am Chem Soc       Date:  2020-02-20       Impact factor: 15.419

7.  Construction of multi-substituted pyrazoles via potassium carbonate-mediated [3 + 2] cycloaddition of in situ generated nitrile imines with cinnamic aldehydes.

Authors:  Mei-Mei Li; Hui Huang; Wanrong Tian; Yiru Pu; Chaozheng Zhang; Jirui Yang; Qing Ren; Feiyan Tao; Yun Deng; Jun Lu
Journal:  RSC Adv       Date:  2022-04-29       Impact factor: 4.036
  7 in total

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