Literature DB >> 16869112

Treatment of cognitive deficits in schizophrenia.

Christopher R Bowie1, Philip D Harvey.   

Abstract

Cognitive deficits are a core feature of schizophrenia and are a major contributor to functional disability. These impairments persist even when patients are in remission of psychotic symptoms and have, to date, eluded treatment. While some improvement is noted with existing medications, current trends in this field include studying and searching for adjunctive treatments to truly remediate cognitive dysfunction in schizophrenia. Psychosocial treatments have demonstrated some success, but the use of existing cognitive enhancers in schizophrenia treatment has provided little cognitive improvement. This paper reviews the current status of cognitive deficit treatment in schizophrenia and offers suggestions for future work.

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Year:  2006        PMID: 16869112

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN: 1472-4472


  13 in total

1.  Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine.

Authors:  David M Thomson; Allan McVie; Brian J Morris; Judith A Pratt
Journal:  Psychopharmacology (Berl)       Date:  2010-09-29       Impact factor: 4.530

2.  Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.

Authors:  Herman J Ng; Edward R Whittemore; Minhtam B Tran; Derk J Hogenkamp; Ron S Broide; Timothy B Johnstone; Lijun Zheng; Karen E Stevens; Kelvin W Gee
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-30       Impact factor: 11.205

Review 3.  Cognition and resting-state functional connectivity in schizophrenia.

Authors:  Julia M Sheffield; Deanna M Barch
Journal:  Neurosci Biobehav Rev       Date:  2015-12-14       Impact factor: 8.989

Review 4.  Converging models of schizophrenia--Network alterations of prefrontal cortex underlying cognitive impairments.

Authors:  Takeshi Sakurai; Nao J Gamo; Takatoshi Hikida; Sun-Hong Kim; Toshiya Murai; Toshifumi Tomoda; Akira Sawa
Journal:  Prog Neurobiol       Date:  2015-09-25       Impact factor: 11.685

Review 5.  Reversal learning and attentional set-shifting in mice.

Authors:  Gregory B Bissonette; Elizabeth M Powell
Journal:  Neuropharmacology       Date:  2011-03-23       Impact factor: 5.250

Review 6.  Is schizophrenia a syndrome of accelerated aging?

Authors:  Brian Kirkpatrick; Erick Messias; Philip D Harvey; Emilio Fernandez-Egea; Christopher R Bowie
Journal:  Schizophr Bull       Date:  2007-12-21       Impact factor: 9.306

7.  Implicit motor sequence learning in schizophrenia and in old age: reduced performance only in the third session.

Authors:  Claudia Cornelis; Livia J De Picker; Peter De Boer; Glenn Dumont; Violette Coppens; Anne Morsel; Luc Janssens; Maarten Timmers; Bernard G C Sabbe; Manuel Morrens; Wouter Hulstijn
Journal:  Exp Brain Res       Date:  2016-08-09       Impact factor: 1.972

8.  Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem.

Authors:  Dwight Dickinson; Philip D Harvey
Journal:  Schizophr Bull       Date:  2008-08-09       Impact factor: 9.306

9.  Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.

Authors:  K S Alexander; A Pocivavsek; H-Q Wu; M L Pershing; R Schwarcz; J P Bruno
Journal:  Neuroscience       Date:  2013-02-06       Impact factor: 3.590

Review 10.  Repetitive Transcranial Magnetic Stimulation as a Therapeutic and Probe in Schizophrenia: Examining the Role of Neuroimaging and Future Directions.

Authors:  Stephen J Brandt; Halimah Y Oral; Carla Arellano-Bravo; Martin H Plawecki; Tom A Hummer; Michael M Francis
Journal:  Neurotherapeutics       Date:  2021-04-12       Impact factor: 7.620

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