BACKGROUND AND OBJECTIVE: It is unknown if the decreased ability to relax airway smooth muscles in asthma and other inflammatory airways disorders can be influenced by low level laser therapy (LLLT) irradiation. To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats. STUDY DESIGN/ MATERIALS AND METHODS: Controlled rat study where trachea was dissected and mounted in an organ bath apparatus with or without a TNF-alpha solution. RESULTS: Low level laser therapy administered perpendicularly to a point in the middle of the dissected trachea with a wavelength of 655 nm and a dose of 2.6 J/cm(2), partially restored TSM relaxation response to isoproterenol. Tension reduction was 47.0 % (+/-2.85) in the laser-irradiated group compared to 22.0% (+/-2.21) in the control group (P < 0.01). Accumulation of cAMP was almost normalized after LLLT at 22.3 pmol/mg (+/-2.1) compared to 17.6 pmol/mg (+/-2.1) in the non-irradiated control group (P < 0.01). CONCLUSION: Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol. (c) 2006 Wiley-Liss, Inc.
BACKGROUND AND OBJECTIVE: It is unknown if the decreased ability to relax airway smooth muscles in asthma and other inflammatory airways disorders can be influenced by low level laser therapy (LLLT) irradiation. To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats. STUDY DESIGN/ MATERIALS AND METHODS: Controlled rat study where trachea was dissected and mounted in an organ bath apparatus with or without a TNF-alpha solution. RESULTS: Low level laser therapy administered perpendicularly to a point in the middle of the dissected trachea with a wavelength of 655 nm and a dose of 2.6 J/cm(2), partially restored TSM relaxation response to isoproterenol. Tension reduction was 47.0 % (+/-2.85) in the laser-irradiated group compared to 22.0% (+/-2.21) in the control group (P < 0.01). Accumulation of cAMP was almost normalized after LLLT at 22.3 pmol/mg (+/-2.1) compared to 17.6 pmol/mg (+/-2.1) in the non-irradiated control group (P < 0.01). CONCLUSION: Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol. (c) 2006 Wiley-Liss, Inc.
Authors: Flávia Mafra de Lima; Leonardo M Moreira; A B Villaverde; Regiane Albertini; Hugo C Castro-Faria-Neto; Flávio Aimbire Journal: Lasers Med Sci Date: 2010-12-24 Impact factor: 3.161
Authors: Flávia Mafra de Lima; Jan M Bjordal; Regiane Albertini; Fábio V Santos; Flavio Aimbire Journal: Lasers Med Sci Date: 2010-09 Impact factor: 3.161
Authors: F Aimbire; A P Ligeiro de Oliveira; R Albertini; J C Corrêa; C B Ladeira de Campos; J P Lyon; J A Silva; M S Costa Journal: Inflammation Date: 2008-04-18 Impact factor: 4.092
Authors: Flávio Aimbire; Flávia Mafra de Lima; Maricilia S Costa; Regiane Albertini; João Carlos Correa; Vegard V Iversen; Jan M Bjordal Journal: Lasers Med Sci Date: 2008-11-12 Impact factor: 3.161
Authors: Pamela Nithzi Bricher Choque; Rodolfo P Vieira; Luis Ulloa; Caren Grabulosa; Maria Claudia Irigoyen; Katia De Angelis; Ana Paula Ligeiro De Oliveira; Kevin J Tracey; Valentin A Pavlov; Fernanda Marciano Consolim-Colombo Journal: Front Pharmacol Date: 2021-05-04 Impact factor: 5.810