Literature DB >> 16867973

Impact of an Adherence Program on the Health and Outlook of HIV-Infected Patients Failing Antiretroviral Therapy.

Michael F Parry1, Pamela Wright, Julie Stewart, Gavin X McLeod, James Tucker, Amy R Weinberg.   

Abstract

BACKGROUND: We prospectively studied the impact of an adherence counselor on the outcome of patients failing antiretroviral therapy because of nonadherence.
METHODS: Forty-six patients, identified as chronically nonadherent were enrolled. Individual attention was provided using the information, motivation and behavioral methodology. HIV RNA (viral load, in copies/mL), CD4 count (in cells/mm(3)), and body weight before and after the adherence counselor were measured. Qualitative outcome and patient satisfaction were assessed by deidentified third-party interviews.
RESULTS: Over half completed at least 1 year; only 8 patients were lost to follow-up. Mean CD4 counts increased significantly (P < .05) for completers at 6 and 12 months. Viral loads decreased between baseline and 6 months. Most clients reported subjective benefit from working with the adherence counselor.
CONCLUSION: Although few clients showed complete virologic suppression, the value of an adherence counselor was validated. Longer term adherence programs should be evaluated.

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Year:  2005        PMID: 16867973     DOI: 10.1177/1545109705281897

Source DB:  PubMed          Journal:  J Int Assoc Physicians AIDS Care (Chic)        ISSN: 1545-1097


  4 in total

Review 1.  Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies.

Authors:  Till Bärnighausen; Krisda Chaiyachati; Natsayi Chimbindi; Ashleigh Peoples; Jessica Haberer; Marie-Louise Newell
Journal:  Lancet Infect Dis       Date:  2011-10-24       Impact factor: 25.071

Review 2.  A systematic review comparing antiretroviral adherence descriptive and intervention studies conducted in the USA.

Authors:  Margarete Sandelowski; Corrine I Voils; Yunkyung Chang; Eun-Jeong Lee
Journal:  AIDS Care       Date:  2009-08

Review 3.  A mixed-methods approach to synthesizing evidence on mediators of intervention effects.

Authors:  Jennifer Leeman; Yunkyung Chang; Corrine I Voils; Jamie L Crandell; Margarete Sandelowski
Journal:  West J Nurs Res       Date:  2011-03-17       Impact factor: 1.967

Review 4.  Implementation of antiretroviral therapy adherence interventions: a realist synthesis of evidence.

Authors:  Jennifer Leeman; Yun Kyung Chang; Eun Jeong Lee; Corrine I Voils; Jamie Crandell; Margarete Sandelowski
Journal:  J Adv Nurs       Date:  2010-09       Impact factor: 3.187

  4 in total

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