Tartaric acid derivatives as chiral sources for enantioseparation in liquid chromatography.

Based on a systematic review of the usage of tartaric acid as a chiral source to resolve enantiomeric compounds, a concept is presented for synthesizing new chiral stationary phases utilizing tartaric acid derivatives as the chiral selector. The results indicate that the conformational change of one of the three optically active centres of the chiral selector strongly affects its enantioselectivity for certain types of compound.