Literature DB >> 16867687

Determination of isotretinoin or etretinate and their major metabolites in human blood by reversed-phase high-performance liquid chromatography.

C J Buggé1, L C Rodriguez, F M Vane.   

Abstract

A method is described for the quantitative analysis of isotretinoin and its 4-oxo metabolite, or of etretinate and its principal metabolites, in human blood in the range 10-2000 ng/ml. Following a simple one-step extraction, the compounds are determined by reversed-phase high-performance liquid chromatography (HPLC) with gradient elution and detection at 365 nm. This highly specific method separates the cis and trans isomers of the parent compounds and their metabolites. Examples are given of the application of this method to clinical studies of these two therapeutically important retinoids.

Entities:  

Year:  1985        PMID： 16867687     DOI： 10.1016/0731-7085(85)80032-7

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  5 in total

1.  Dose-proportional absorption of etretinate after doses of 25, 50, 75, and 100 mg.

Authors:  R J Wills; L C Rodriguez; A H Lin; C Puccini; W A Colburn
Journal:  Pharm Res       Date:  1987-10       Impact factor: 4.200

2.  Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group.

Authors:  Judith G Villablanca; Wendy B London; Arlene Naranjo; Patrick McGrady; Matthew M Ames; Joel M Reid; Renee M McGovern; Sarah A Buhrow; Hollie Jackson; Enno Stranzinger; Brenda J Kitchen; Paul M Sondel; Marguerite T Parisi; Barry Shulkin; Gregory A Yanik; Susan L Cohn; C Patrick Reynolds
Journal:  Clin Cancer Res       Date:  2011-09-09       Impact factor: 12.531

3.  Vitamin A supplementation increases levels of retinoic acid compounds in human plasma: possible implications for teratogenesis.

Authors:  C Eckhoff; H Nau
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

4.  Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro.

Authors:  E A Duell; A Aström; C E Griffiths; P Chambon; J J Voorhees
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

5.  Non-medication Acquired Sticky Skin: Case Report of Idiopathic Acquired Cutaneous Adherence and Review of Medication-Induced Sticky Skin.

Authors:  Adrija K Darsha; Philip R Cohen
Journal:  Cureus       Date:  2021-11-14
  5 in total

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