Overpressured layer chromatography and its applicability in pharmaceutical and biomedical analysis.

The principles and potential of overpressured layer chromatography (OPLC) are presented and illustrated by some applications in the field of pharmaceutical and biomedical analysis. The efficiency of analytical and preparative OPLC systems depends on the optimum solvent front velocity, the quality of sorbent layer and sample application. OPLC as an instrumentalized version of planar liquid chromatography offers distinct advantages in the analysis of various chemical substance groups over TLC and HPTLC. The full exploitation of these advantages in future work is an expected development.