Chemometrics in pharmaceutical analysis.

Chemometrics is a science where chemistry and pharmaceutical science meet statistics and software. The primary focus of chemometrics involves the use of mathematical or software procedures in particular, both to develop analytical methods and to analyse the signals and results obtained. This paper focusses on chromatography and on how chemometrics has been applied to chromatographic problems in pharmaceutical and biomedical analysis. Examples of several chemometric techniques are given and recent developments in the use of optimization methods, regression methodology, multivariate analysis and expert systems are discussed.