OBJECTIVE: This study aimed to assess the lipid-lowering properties of omega-3 fatty acids (also known as n-3 polyunsaturated fatty acids) in a group of patients taking clozapine. METHOD: Twenty-eight persons suffering from schizophrenia or schizoaffective disorder and currently taking clozapine participated in an open-label single-arm trial. Participants received supplements of 10 g of fish oil (containing 1.8 g of eicosopentaenoic acid and 1.2 g of docosahexaenoic acid) for a period of 28 days. Plasma lipids were measured on days 0 and 28. RESULTS: This study demonstrated high rates of lipid abnormalities in the participants. Participants taking omega-3 fatty acids demonstrated a statistically significant reduction in mean serum triglyceride levels of 22%. There was an associated increase in total cholesterol (6.6%) and low-density lipoprotein cholesterol (22%). Common side-effects included fishy burps or breath, but no serious side-effects or interactions where observed. CONCLUSION: Omega-3 fatty acids may be of value in patients taking clozapine and who have elevated serum triglyceride levels. Limitations of the study, practical implications and directions for future research are discussed.
OBJECTIVE: This study aimed to assess the lipid-lowering properties of omega-3 fatty acids (also known as n-3 polyunsaturated fatty acids) in a group of patients taking clozapine. METHOD: Twenty-eight persons suffering from schizophrenia or schizoaffective disorder and currently taking clozapine participated in an open-label single-arm trial. Participants received supplements of 10 g of fish oil (containing 1.8 g of eicosopentaenoic acid and 1.2 g of docosahexaenoic acid) for a period of 28 days. Plasma lipids were measured on days 0 and 28. RESULTS: This study demonstrated high rates of lipid abnormalities in the participants. Participants taking omega-3 fatty acids demonstrated a statistically significant reduction in mean serum triglyceride levels of 22%. There was an associated increase in total cholesterol (6.6%) and low-density lipoprotein cholesterol (22%). Common side-effects included fishy burps or breath, but no serious side-effects or interactions where observed. CONCLUSION:Omega-3 fatty acids may be of value in patients taking clozapine and who have elevated serum triglyceride levels. Limitations of the study, practical implications and directions for future research are discussed.
Authors: Robert K McNamara; Ronald Jandacek; Therese Rider; Patrick Tso; Allyson Cole-Strauss; Jack W Lipton Journal: Schizophr Res Date: 2011-03-31 Impact factor: 4.939
Authors: Robert K McNamara; Ronald Jandacek; Therese Rider; Patrick Tso; Allyson Cole-Strauss; Jack W Lipton Journal: Schizophr Res Date: 2011-04-07 Impact factor: 4.939
Authors: Robert K McNamara; I Jack Magrisso; Rylon Hofacer; Ronald Jandacek; Therese Rider; Patrick Tso; Stephen C Benoit Journal: Pharmacol Res Date: 2012-06-29 Impact factor: 7.658
Authors: Delbert G Robinson; Juan A Gallego; Majnu John; Lauren A Hanna; Jian-Ping Zhang; Michael L Birnbaum; Jessica Greenberg; Melissa Naraine; Bart D Peters; Robert K McNamara; Anil K Malhotra; Philip R Szeszko Journal: Schizophr Res Date: 2018-09-19 Impact factor: 4.939
Authors: Robert K McNamara; Ronald Jandacek; Therese Rider; Patrick Tso; Yogesh Dwivedi; Ghanshyam N Pandey Journal: Cardiovasc Psychiatry Neurol Date: 2013-02-27