| Literature DB >> 1686585 |
G M Ramakers1, B W Peeters, J M Vossen, A M Coenen.
Abstract
The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5 microliters) and AMPA (0.1 pmol/5 microliters), kainic acid (0.01 nmol/5 microliters) or NMDA (50 pmol/5 microliters) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes.Entities:
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Year: 1991 PMID： 1686585 DOI： 10.1016/0920-1211(91)90023-9
Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045