Literature DB >> 16865254

Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: a comparison with healthy gastric mucosa.

V Tugnoli1, A Mucci, L Schenetti, V Righi, C Calabrese, A Fabbri, G Di Febo, M R Tosi.   

Abstract

The present study reports the characteristics of the biochemical profile of human gastric adenocarcinoma in comparison with that of healthy gastric mucosa, using ex vivo HR-MAS Magnetic Resonance Spectroscopy. Healthy human mucosa is mainly characterized by the presence of small metabolites (more than 50 identified) and macromolecules, whereas the adenocarcinoma spectra are dominated by the presence of signals due to triglycerides, whose content on the contrary is very low in healthy gastric mucosa. The use of spin-echo experiments enable us to detect some metabolites in the unhealthy tissues and to determine their variation with respect to the healthy ones. We have observed that the Cho:ChoCC ratio changes from 20:80 in the healthy tissues to 80:20 in the neoplastic gastric mucosa.

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Year:  2006        PMID： 16865254     DOI： 10.3892/or.16.3.543

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  10 in total

Review 1.  Applications of high-resolution magic angle spinning MRS in biomedical studies II-Human diseases.

Authors:  Christopher Dietz; Felix Ehret; Francesco Palmas; Lindsey A Vandergrift; Yanni Jiang; Vanessa Schmitt; Vera Dufner; Piet Habbel; Johannes Nowak; Leo L Cheng
Journal:  NMR Biomed       Date:  2017-09-15       Impact factor: 4.044

2.  Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.

Authors:  Bagganahalli S Somashekar; Pachiyappan Kamarajan; Theodora Danciu; Yvonne L Kapila; Arul M Chinnaiyan; Thekkelnaycke M Rajendiran; Ayyalusamy Ramamoorthy
Journal:  J Proteome Res       Date:  2011-10-18       Impact factor: 4.466

3.  EPA or DHA supplementation increases triacylglycerol, but not phospholipid, levels in isolated rat cardiomyocytes.

Authors:  Valeria Righi; Mattia Di Nunzio; Francesca Danesi; Luisa Schenetti; Adele Mucci; Elisa Boschetti; Pierluigi Biagi; Sergio Bonora; Vitaliano Tugnoli; Alessandra Bordoni
Journal:  Lipids       Date:  2011-05-05       Impact factor: 1.880

4.  Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumours?

Authors:  Iola F Duarte; Cláudia M Rocha; António S Barros; Ana M Gil; Brian J Goodfellow; Isabel M Carreira; João Bernardo; Ana Gomes; Vitor Sousa; Lina Carvalho
Journal:  Virchows Arch       Date:  2010-10-13       Impact factor: 4.064

5.  HR-MAS NMR tissue metabolomic signatures cross-validated by mass spectrometry distinguish bladder cancer from benign disease.

Authors:  Pratima Tripathi; Bagganahalli S Somashekar; M Ponnusamy; Amy Gursky; Stephen Dailey; Priya Kunju; Cheryl T Lee; Arul M Chinnaiyan; Thekkelnaycke M Rajendiran; Ayyalusamy Ramamoorthy
Journal:  J Proteome Res       Date:  2013-06-18       Impact factor: 4.466

Review 6.  Metabolic reprogramming results in abnormal glycolysis in gastric cancer: a review.

Authors:  Yuanda Liu; Ze Zhang; Junyang Wang; Chao Chen; Xiaohuan Tang; Jiaming Zhu; Jingjing Liu
Journal:  Onco Targets Ther       Date:  2019-02-13       Impact factor: 4.147

7.  Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy.

Authors:  Agnieszka Skorupa; Mateusz Ciszek; Ewa Chmielik; Łukasz Boguszewicz; Małgorzata Oczko-Wojciechowska; Małgorzata Kowalska; Dagmara Rusinek; Tomasz Tyszkiewicz; Aneta Kluczewska-Gałka; Agnieszka Czarniecka; Barbara Jarząb; Maria Sokół
Journal:  Sci Rep       Date:  2021-01-14       Impact factor: 4.379

8.  Identification of 14 Differentially-Expressed Metabolism-Related Genes as Potential Targets of Gastric Cancer by Integrated Proteomics and Transcriptomics.

Authors:  Yongxin Zhang; Wenwei Liu; Wei Feng; Xiaofeng Wang; Tianxiang Lei; Zehong Chen; Wu Song
Journal:  Front Cell Dev Biol       Date:  2022-02-21

9.  Characterization of lipomatous tumors with high-resolution 1H MRS at 17.6T: Do benign lipomas, atypical lipomatous tumors and liposarcomas have a distinct metabolic signature?

Authors:  Santosh Kumar Bharti; Brett A Shannon; Raj Kumar Sharma; Adam S Levin; Carol D Morris; Zaver M Bhujwalla; Laura M Fayad
Journal:  Front Oncol       Date:  2022-09-09       Impact factor: 5.738

10.  A systematic review of metabolomic profiling of gastric cancer and esophageal cancer.

Authors:  Sha Huang; Yang Guo; Zhexuan Li; Yang Zhang; Tong Zhou; Weicheng You; Kaifeng Pan; Wenqing Li
Journal:  Cancer Biol Med       Date:  2020-02-15       Impact factor: 4.248
  10 in total

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