Reut Gruber1, Natalie Grizenko2, George Schwartz2, Leila Ben Amor2, Julie Gauthier2, Rosherrie de Guzman2, Ridha Joober2. 1. Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.. Electronic address: reut.gruber@douglas.mcgill.ca. 2. Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
Abstract
OBJECTIVE: To examine whether COMT (catechol-O-methyltransferase) polymorphism modulates aspects of sleep in children diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHOD: Nightly sleep actigraphic recordings during a double-blind, placebo-controlled, crossover clinical study (1 week of 0.5 mg/kg MPH; 1 week of placebo) were obtained for 34 children, 7.4 to 12 years old, diagnosed with ADHD (DSM-IV). Diagnosis was generated by the Diagnostic Interview Schedule for Children and was confirmed by multidisciplinary consensus. RESULTS:Children who were Val allele carriers had poorer sleep continuity compared with children with the Met-Met genotype while receiving a placebo and while receiving methylphenidate. CONCLUSIONS: The findings of the present study support the hypothesis that sleep disturbances in children with ADHD are related to the underlying pathophysiology of the disorder.
RCT Entities:
OBJECTIVE: To examine whether COMT (catechol-O-methyltransferase) polymorphism modulates aspects of sleep in children diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHOD: Nightly sleep actigraphic recordings during a double-blind, placebo-controlled, crossover clinical study (1 week of 0.5 mg/kg MPH; 1 week of placebo) were obtained for 34 children, 7.4 to 12 years old, diagnosed with ADHD (DSM-IV). Diagnosis was generated by the Diagnostic Interview Schedule for Children and was confirmed by multidisciplinary consensus. RESULTS:Children who were Val allele carriers had poorer sleep continuity compared with children with the Met-Met genotype while receiving a placebo and while receiving methylphenidate. CONCLUSIONS: The findings of the present study support the hypothesis that sleep disturbances in children with ADHD are related to the underlying pathophysiology of the disorder.
Authors: Alice M Gregory; Jessica C Agnew-Blais; Timothy Matthews; Terrie E Moffitt; Louise Arseneault Journal: J Clin Child Adolesc Psychol Date: 2016-08-02
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Authors: Ole Jakob Storebø; Erica Ramstad; Helle B Krogh; Trine Danvad Nilausen; Maria Skoog; Mathilde Holmskov; Susanne Rosendal; Camilla Groth; Frederik L Magnusson; Carlos R Moreira-Maia; Donna Gillies; Kirsten Buch Rasmussen; Dorothy Gauci; Morris Zwi; Richard Kirubakaran; Bente Forsbøl; Erik Simonsen; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2015-11-25