OBJECTIVE: Liquorice-induced increase in blood pressure (BP) is more profound in subjects with essential hypertension (HT) than in healthy individuals. Liquorice induces pseudohyperaldosteronism by inhibiting the 11beta-hydroxysteroid dehydrogenase type 2 and is also known to inhibit the renin-angiotensin-aldosterone system (RAAS). We explored the difference in response in BP, considering the RAAS and the genders. DESIGN: Patients with HT (eight men and three women, mean age 40.7 years) and healthy controls (13 men and 12 women, mean age 31.2 years) consumed 100 g of liquorice (150 mg glycyrrhetinic acid) daily for 4 weeks. METHODS: Blood, urine samples and BP were evaluated before and after 4 weeks of liquorice consumption and 4 weeks after cessation of liquorice consumption. RESULTS: The relative change in serum aldosterone levels differed between the genders (p < 0.02), men being more responsive than women, but not between patients with HT and healthy subjects. CONCLUSION: The liquorice-induced inhibition of aldosterone secretion differs between the genders and is not influenced by the BP levels. This difference between the genders has not been exposed before.
OBJECTIVE: Liquorice-induced increase in blood pressure (BP) is more profound in subjects with essential hypertension (HT) than in healthy individuals. Liquorice induces pseudohyperaldosteronism by inhibiting the 11beta-hydroxysteroid dehydrogenase type 2 and is also known to inhibit the renin-angiotensin-aldosterone system (RAAS). We explored the difference in response in BP, considering the RAAS and the genders. DESIGN:Patients with HT (eight men and three women, mean age 40.7 years) and healthy controls (13 men and 12 women, mean age 31.2 years) consumed 100 g of liquorice (150 mg glycyrrhetinic acid) daily for 4 weeks. METHODS: Blood, urine samples and BP were evaluated before and after 4 weeks of liquorice consumption and 4 weeks after cessation of liquorice consumption. RESULTS: The relative change in serum aldosterone levels differed between the genders (p < 0.02), men being more responsive than women, but not between patients with HT and healthy subjects. CONCLUSION: The liquorice-induced inhibition of aldosterone secretion differs between the genders and is not influenced by the BP levels. This difference between the genders has not been exposed before.
Authors: Mohamed Réda Sefrioui; Ibrahim Sbai El Othmani; Halima Filali; Sanae Derfoufi; Soufiane Derraji; Adnane Benmoussa; Amal Ait Haj Said Journal: Med Pharm Rep Date: 2021-04-29
Authors: Miia H Leskinen; Elina J Hautaniemi; Anna M Tahvanainen; Jenni K Koskela; Marika Päällysaho; Antti J Tikkakoski; Mika Kähönen; Tiit Kööbi; Onni Niemelä; Jukka Mustonen; Ilkka H Pörsti Journal: PLoS One Date: 2014-08-25 Impact factor: 3.240
Authors: Elina J Hautaniemi; Anna M Tahvanainen; Jenni K Koskela; Antti J Tikkakoski; Mika Kähönen; Marko Uitto; Kalle Sipilä; Onni Niemelä; Jukka Mustonen; Ilkka H Pörsti Journal: Sci Rep Date: 2017-09-08 Impact factor: 4.379
Authors: Elina J Hautaniemi; Antti J Tikkakoski; Arttu Eräranta; Mika Kähönen; Esa Hämäläinen; Ursula Turpeinen; Heini Huhtala; Jukka Mustonen; Ilkka H Pörsti Journal: PLoS One Date: 2019-10-18 Impact factor: 3.240