Literature DB >> 1686316

Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells.

J E Taylor1, J P Moreau, L Baptiste, T W Moody.   

Abstract

Two endocrinologically active octapeptide analogues (BIM-23014 C and BIM-23034) of somatostatin (SRIF) containing either an N- or C-terminal 3-(2-naphthyl)-D-Ala residue were examined for their ability to inhibit the in vitro receptor binding, clonal growth, and vasoactive intestinal peptide (VIP)-stimulated cyclic AMP formation in human small cell lung cancer cell (SCLC) line NCI-H345. Both SRIF peptides inhibited [125I]SRIF(Tyr11)-14 binding with IC50 values in the low nM range. Colony formation in the in vitro SCLC growth assay was also inhibited in the same concentration range, as was VIP-stimulated cyclic AMP formation. Therefore, octapeptide analogues of SRIF function as SCLC SRIF receptor agonists.

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Year:  1991        PMID： 1686316     DOI： 10.1016/0196-9781(91)90143-d

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  6 in total

1.  Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases.

Authors:  Gen-You Yao; Ji-Lin Zhou; Mao-De Lai; Xiao-Qing Chen; Pei-Hui Chen
Journal:  World J Gastroenterol       Date:  2003-04       Impact factor: 5.742

2.  Bombesin/gastrin-releasing peptide receptor antagonists increase the ability of histone deacetylase inhibitors to reduce lung cancer proliferation.

Authors:  Terry W Moody; Tomoo Nakagawa; Yang Kang; Sonia Jakowlew; Daniel Chan; Robert T Jensen
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

3.  Indium-111 pentetreotide in the diagnostic work-up of patients with bronchogenic carcinoma.

Authors:  C M Kirsch; J von Pawel; I Grau; K Tatsch
Journal:  Eur J Nucl Med       Date:  1994-12

4.  Scintigraphic imaging of small-cell lung cancer with [111In]pentetreotide, a radiolabelled somatostatin analogue.

Authors:  K J O'Byrne; J T Ennis; P J Freyne; L J Clancy; J S Prichard; D N Carney
Journal:  Br J Cancer       Date:  1994-04       Impact factor: 7.640

5.  Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice.

Authors:  J Pinski; A V Schally; G Halmos; K Szepeshazi; K Groot; K O'Byrne; R Z Cai
Journal:  Br J Cancer       Date:  1994-11       Impact factor: 7.640

6.  Effects of angiopeptin on transplant arteriosclerosis in the rat.

Authors:  M L Akyürek; A Wanders; M Aurivillius; E Larsson; K Funa; B C Fellström
Journal:  Transpl Int       Date:  1995       Impact factor: 3.782
  6 in total

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