| Literature DB >> 16862269 |
Gerasimos Malandrinos1, Maria Louloudi, Nick Hadjiliadis.
Abstract
Thiamine dependent enzymes catalyze ligase and lyase reactions near a carbonyl moiety. Chemical models for these reactions serve as useful tools to substantiate a detailed mechanism of action. This tutorial review covers all such studies performed thus far, emphasizing the role of each part around the active site and the conformation of the cofactor during catalysis.Entities:
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Year: 2006 PMID： 16862269 DOI： 10.1039/b514511m
Source DB: PubMed Journal: Chem Soc Rev ISSN： 0306-0012 Impact factor: 54.564