Literature DB >> 16861681

Murine model of infection by Tropheryma whipplei.

Séverine Genot1, Andreas Stein, Hubert Lepidi, Melanie Ihrig, Didier Raoult, Jean-Louis Mege.   

Abstract

We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.

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Year:  2006        PMID： 16861681      PMCID： PMC1539611          DOI： 10.1128/IAI.00283-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

Review 1.  Whipple's disease and "Tropheryma whippelii".

Authors:  F Dutly; M Altwegg
Journal:  Clin Microbiol Rev       Date:  2001-07       Impact factor: 26.132

2.  Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages.

Authors:  Benoît Desnues; Hubert Lepidi; Didier Raoult; Jean-Louis Mege
Journal:  J Infect Dis       Date:  2005-09-30       Impact factor: 5.226

Review 3.  Intrahepatic immunity: a tale of two sites?

Authors:  David G Bowen; Geoffrey W McCaughan; Patrick Bertolino
Journal:  Trends Immunol       Date:  2005-10       Impact factor: 16.687

4.  Sarcoid-like forms of Whipple's disease. Report of 2 cases.

Authors:  A Rouillon; C J Menkes; J C Gerster; I Perez-Sawka; M Forest
Journal:  J Rheumatol       Date:  1993-06       Impact factor: 4.666

5.  Dysregulated peripheral and mucosal Th1/Th2 response in Whipple's disease.

Authors:  Thomas Marth; Nicole Kleen; Andreas Stallmach; Sabine Ring; Sheriff Aziz; Carsten Schmidt; Warren Strober; Martin Zeitz; Thomas Schneider
Journal:  Gastroenterology       Date:  2002-11       Impact factor: 22.682

6.  Lymphedema, lymphocytic myocarditis, and sarcoidlike granulomatosis. Manifestations of Whipple's disease.

Authors:  J F Southern; R A Moscicki; C Magro; G R Dickersin; J T Fallon; K J Bloch
Journal:  JAMA       Date:  1989-03-10       Impact factor: 56.272

7.  IL-16 is critical for Tropheryma whipplei replication in Whipple's disease.

Authors:  Benoît Desnues; Didier Raoult; Jean-Louis Mege
Journal:  J Immunol       Date:  2005-10-01       Impact factor: 5.422

8.  Cultivation of the bacillus of Whipple's disease.

Authors:  D Raoult; M L Birg; B La Scola; P E Fournier; M Enea; H Lepidi; V Roux; J C Piette; F Vandenesch; D Vital-Durand; T J Marrie
Journal:  N Engl J Med       Date:  2000-03-02       Impact factor: 91.245

9.  Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei.

Authors:  Stephen D Bentley; Matthias Maiwald; Lee D Murphy; Mark J Pallen; Corin A Yeats; Lynn G Dover; Halina T Norbertczak; Gurdyal S Besra; Michael A Quail; David E Harris; Axel von Herbay; Arlette Goble; Simon Rutter; Robert Squares; Stephen Squares; Bart G Barrell; Julian Parkhill; David A Relman
Journal:  Lancet       Date:  2003-02-22       Impact factor: 79.321

Review 10.  Whipple's disease.

Authors:  Thomas Marth; Didier Raoult
Journal:  Lancet       Date:  2003-01-18       Impact factor: 79.321
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  1 in total

1.  An experimental mouse model to establish Tropheryma whipplei as a diarrheal agent.

Authors:  Khatoun Al Moussawi; Nada Malou; Jean-Louis Mege; Didier Raoult; Benoit Desnues
Journal:  J Infect Dis       Date:  2011-07-01       Impact factor: 5.226
  1 in total

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