Literature DB >> 16861680

Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.

Kristin L DeBord1, Deborah M Anderson, Melanie M Marketon, Katie A Overheim, R William DePaolo, Nancy A Ciletti, Bana Jabri, Olaf Schneewind.   

Abstract

In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.

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Year:  2006        PMID： 16861680      PMCID： PMC1539636          DOI： 10.1128/IAI.01860-05

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  30 in total

1.  Protection conferred by a fully recombinant sub-unit vaccine against Yersinia pestis in male and female mice of four inbred strains.

Authors:  S M Jones; F Day; A J Stagg; E D Williamson
Journal:  Vaccine       Date:  2000-09-15       Impact factor: 3.641

Review 2.  Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen).

Authors:  Robert R Brubaker
Journal:  Infect Immun       Date:  2003-07       Impact factor: 3.441

3.  A low-Ca2+ response operon encodes the V antigen of Yersinia pestis.

Authors:  R D Perry; P A Harmon; W S Bowmer; S C Straley
Journal:  Infect Immun       Date:  1986-11       Impact factor: 3.441

4.  Mutation rate to nonpigmentation in Pasteurella pestis.

Authors:  R R Brubaker
Journal:  J Bacteriol       Date:  1969-06       Impact factor: 3.490

Review 5.  Hijacking and exploitation of IL-10 by intracellular pathogens.

Authors:  S Redpath; P Ghazal; N R Gascoigne
Journal:  Trends Microbiol       Date:  2001-02       Impact factor: 17.079

6.  Anti-V antigen antibody protects macrophages from Yersinia pestis -induced cell death and promotes phagocytosis.

Authors:  S Weeks; J Hill; A Friedlander; S Welkos
Journal:  Microb Pathog       Date:  2002-05       Impact factor: 3.738

7.  Protective efficacy of a fully recombinant plague vaccine in the guinea pig.

Authors:  S M Jones; K F Griffin; I Hodgson; E D Williamson
Journal:  Vaccine       Date:  2003-09-08       Impact factor: 3.641

Review 8.  Yersinia type III secretion: send in the effectors.

Authors:  Guy R Cornelis
Journal:  J Cell Biol       Date:  2002-08-05       Impact factor: 10.539

9.  Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression.

Authors:  Andreas Sing; Dagmar Rost; Natalia Tvardovskaia; Andreas Roggenkamp; Agnès Wiedemann; Carsten J Kirschning; Martin Aepfelbacher; Jürgen Heesemann
Journal:  J Exp Med       Date:  2002-10-21       Impact factor: 14.307

10.  A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague.

Authors:  Shixia Wang; Destin Heilman; Fangjun Liu; Theodore Giehl; Swati Joshi; Xiaoyun Huang; Te-hui Chou; Jon Goguen; Shan Lu
Journal:  Vaccine       Date:  2004-09-03       Impact factor: 3.641
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  36 in total

Review 1.  Interaction between Yersinia pestis and the host immune system.

Authors:  Bei Li; Ruifu Yang
Journal:  Infect Immun       Date:  2008-02-04       Impact factor: 3.441

2.  Amino acid and structural variability of Yersinia pestis LcrV protein.

Authors:  Andrey P Anisimov; Svetlana V Dentovskaya; Evgeniy A Panfertsev; Tat'yana E Svetoch; Pavel Kh Kopylov; Brent W Segelke; Adam Zemla; Maxim V Telepnev; Vladimir L Motin
Journal:  Infect Genet Evol       Date:  2009-10-14       Impact factor: 3.342

3.  Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines.

Authors:  Lauriane E Quenee; Nancy A Ciletti; Derek Elli; Timothy M Hermanas; Olaf Schneewind
Journal:  Vaccine       Date:  2011-07-16       Impact factor: 3.641

4.  Coagulases as determinants of protective immune responses against Staphylococcus aureus.

Authors:  Molly McAdow; Andrea C DeDent; Carla Emolo; Alice G Cheng; Barry N Kreiswirth; Dominique M Missiakas; Olaf Schneewind
Journal:  Infect Immun       Date:  2012-07-23       Impact factor: 3.441

5.  Yersinia pestis IS1541 transposition provides for escape from plague immunity.

Authors:  Claire A Cornelius; Lauriane E Quenee; Derek Elli; Nancy A Ciletti; Olaf Schneewind
Journal:  Infect Immun       Date:  2009-02-23       Impact factor: 3.441

6.  Amino acid residues 196-225 of LcrV represent a plague protective epitope.

Authors:  Lauriane E Quenee; Bryan J Berube; Joshua Segal; Derek Elli; Nancy A Ciletti; Deborah Anderson; Olaf Schneewind
Journal:  Vaccine       Date:  2009-12-10       Impact factor: 3.641

7.  LcrV mutants that abolish Yersinia type III injectisome function.

Authors:  Katherine Given Ligtenberg; Nathan C Miller; Anthony Mitchell; Gregory V Plano; Olaf Schneewind
Journal:  J Bacteriol       Date:  2012-12-07       Impact factor: 3.490

8.  YopR impacts type III needle polymerization in Yersinia species.

Authors:  Bill Blaylock; Bryan J Berube; Olaf Schneewind
Journal:  Mol Microbiol       Date:  2009-12-07       Impact factor: 3.501

9.  Yersinia pestis caf1 variants and the limits of plague vaccine protection.

Authors:  Lauriane E Quenee; Claire A Cornelius; Nancy A Ciletti; Derek Elli; Olaf Schneewind
Journal:  Infect Immun       Date:  2008-03-17       Impact factor: 3.441

10.  Vaccination of mice with a Yop translocon complex elicits antibodies that are protective against infection with F1- Yersinia pestis.

Authors:  Maya I Ivanov; Betty L Noel; Ryan Rampersaud; Patricio Mena; Jorge L Benach; James B Bliska
Journal:  Infect Immun       Date:  2008-09-02       Impact factor: 3.441
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