Andrea K Bial1, Richard L Schilsky, Greg A Sachs. 1. The University of Chicago, Department of Medicine, Sections of Geriatrics and Hematology/Oncology, 5841 S. Maryland Avenue, MC 6098, Chicago, IL 60637, United States. abial@medicine.bsd.uchicago.edu
Abstract
PURPOSE: The risks of both cognitive dysfunction and most cancers increase with age. A literature review was undertaken to identify how cognitive issues in older patients were being assessed in the oncology literature. METHODS: A systematic literature search was undertaken using a number of different search terms and databases to find all relevant articles in oncology and internal medicine journals. RESULTS: Eighty-eight articles were included in the review. Just over half of the articles studied a mixture of cancer types and had fewer than 100 patients. The vast majority of patients being studied were <65 years of age. While a little over half of the articles used >or=3 neuropsychological tests to assess cognition, more than 60 different tests were used to assess cognition. Forty-one percent of the studies were prospective trials, with most of the rest divided between cross-sectional and observational. One-fifth of the articles involved patients at end-of-life. CONCLUSION: The oncology literature contains little information about cognition in older cancer patients. More systematic and comprehensive studies of this important aspect of cancer care in the elderly are necessary.
PURPOSE: The risks of both cognitive dysfunction and most cancers increase with age. A literature review was undertaken to identify how cognitive issues in older patients were being assessed in the oncology literature. METHODS: A systematic literature search was undertaken using a number of different search terms and databases to find all relevant articles in oncology and internal medicine journals. RESULTS: Eighty-eight articles were included in the review. Just over half of the articles studied a mixture of cancer types and had fewer than 100 patients. The vast majority of patients being studied were <65 years of age. While a little over half of the articles used >or=3 neuropsychological tests to assess cognition, more than 60 different tests were used to assess cognition. Forty-one percent of the studies were prospective trials, with most of the rest divided between cross-sectional and observational. One-fifth of the articles involved patients at end-of-life. CONCLUSION: The oncology literature contains little information about cognition in older cancerpatients. More systematic and comprehensive studies of this important aspect of cancer care in the elderly are necessary.
Authors: Fay J Hlubocky; Greg A Sachs; Eric R Larson; Halla S Nimeiri; David Cella; Kristen E Wroblewski; Mark J Ratain; Jeffery M Peppercorn; Christopher K Daugherty Journal: J Clin Oncol Date: 2018-07-09 Impact factor: 44.544
Authors: Federica Andreis; Marco Ferri; Maria Mazzocchi; Fausto Meriggi; Anna Rizzi; Luigina Rota; Brunella Di Biasi; Chiara Abeni; Claudio Codignola; Renzo Rozzini; Alberto Zaniboni Journal: Support Care Cancer Date: 2012-08-11 Impact factor: 3.603