Literature DB >> 16860782

Ethanol withdrawal is accompanied by downregulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons.

Prosper N'Gouemo1, Robert P Yasuda, Martin Morad.   

Abstract

Ethanol withdrawal enhances the current density of calcium (Ca(2+)) channels in inferior colliculus (IC) neurons. The present report shows that ethanol withdrawal markedly enhanced the susceptibility to seizures as it decreased significantly the protein levels of alpha(1B) subunit associated with N-type Ca(2+) channel in IC neurons of animals not tested for seizures. Thus, remodeling of N-type Ca(2+) channels may play an important role in neuronal hyperexcitability that leads to ethanol withdrawal seizures.

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Year:  2006        PMID： 16860782     DOI： 10.1016/j.brainres.2006.06.028

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Alcohol withdrawal upregulates mRNA encoding for CaV2.1-α1 subunit in the rat inferior colliculus.

Authors:  Jamila Newton; Shubhankar Suman; Luli R Akinfiresoye; Kamal Datta; David M Lovinger; Prosper N'Gouemo
Journal:  Alcohol       Date:  2017-09-23       Impact factor: 2.405

2.  Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.

Authors:  Luli R Akinfiresoye; Clive Miranda; David M Lovinger; Prosper N'Gouemo
Journal:  Alcohol Clin Exp Res       Date:  2016-09-26       Impact factor: 3.455

3.  Targeted Inhibition of Upregulated Sodium-Calcium Exchanger in Rat Inferior Colliculus Suppresses Alcohol Withdrawal Seizures.

Authors:  Luli R Akinfiresoye; Jamila Newton; Shubhankar Suman; Kamal Datta; Prosper N'Gouemo
Journal:  Mol Neurobiol       Date:  2022-10-20       Impact factor: 5.682

4.  Seizure susceptibility is associated with altered protein expression of voltage-gated calcium channel subunits in inferior colliculus neurons of the genetically epilepsy-prone rat.

Authors:  Prosper N'Gouemo; Robert Yasuda; Carl L Faingold
Journal:  Brain Res       Date:  2009-10-15       Impact factor: 3.252

5.  Calcium channel dysfunction in inferior colliculus neurons of the genetically epilepsy-prone rat.

Authors:  Prosper N'gouemo; Carl L Faingold; Martin Morad
Journal:  Neuropharmacology       Date:  2008-12-06       Impact factor: 5.250

6.  Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat.

Authors:  Prosper N'Gouemo; Robert P Yasuda; Carl L Faingold
Journal:  Brain Res       Date:  2009-02-27       Impact factor: 3.252

7.  Alcohol withdrawal is associated with a downregulation of large-conductance Ca²⁺-activated K⁺ channels in rat inferior colliculus neurons.

Authors:  Prosper N'Gouemo; Martin Morad
Journal:  Psychopharmacology (Berl)       Date:  2013-11-17       Impact factor: 4.530

8.  Alcohol Withdrawal-Induced Seizure Susceptibility is Associated with an Upregulation of CaV1.3 Channels in the Rat Inferior Colliculus.

Authors:  Prosper N'Gouemo; Luli R Akinfiresoye; Joanne S Allard; David M Lovinger
Journal:  Int J Neuropsychopharmacol       Date:  2015-01-02       Impact factor: 5.176

Review 9.  The Inferior Colliculus in Alcoholism and Beyond.

Authors:  Tanuja Bordia; Natalie M Zahr
Journal:  Front Syst Neurosci       Date:  2020-12-11
  9 in total

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