Literature DB >> 16860751

Signaling in the immunological synapse: defining the optimal size.

Abraham Kupfer1.   

Abstract

In this issue of Immunity, Varma et al. (2006) report that in the synapses between T cells and planar bilayers, T cell receptor (TCR) proximal signaling takes place in peripheral TCR-microclusters that form continually and that TCR signaling ceases when they fuse with the central supramolecular activation cluster.

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Substances：

Year:  2006        PMID： 16860751     DOI： 10.1016/j.immuni.2006.07.005

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  8 in total

1.  SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.

Authors:  Hebin Liu; Marco A Purbhoo; Daniel M Davis; Christopher E Rudd
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-13       Impact factor: 11.205

2.  T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

Authors:  Monika Raab; Hongyan Wang; Yuning Lu; Xin Smith; Zhonglin Wu; Klaus Strebhardt; John E Ladbury; Christopher E Rudd
Journal:  Immunity       Date:  2010-03-25       Impact factor: 31.745

3.  Micropatterning of costimulatory ligands enhances CD4+ T cell function.

Authors:  Keyue Shen; V Kaye Thomas; Michael L Dustin; Lance C Kam
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-27       Impact factor: 11.205

4.  SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.

Authors:  Monika Raab; Xin Smith; Yves Matthess; Klaus Strebhardt; Christopher E Rudd
Journal:  J Biol Chem       Date:  2011-06-13       Impact factor: 5.157

5.  LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

Authors:  Monika Raab; Yuning Lu; Karsten Kohler; Xin Smith; Klaus Strebhardt; Christopher E Rudd
Journal:  Nat Commun       Date:  2017-07-12       Impact factor: 14.919

6.  The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function.

Authors:  George P Bondinas; Antonis K Moustakas; George K Papadopoulos
Journal:  Immunogenetics       Date:  2007-05-12       Impact factor: 2.846

7.  The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.

Authors:  Saso Cemerski; Jayajit Das; Emanuele Giurisato; Mary A Markiewicz; Paul M Allen; Arup K Chakraborty; Andrey S Shaw
Journal:  Immunity       Date:  2008-08-28       Impact factor: 31.745

8.  Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.

Authors:  Praneeth Chitirala; Hsin-Fang Chang; Paloma Martzloff; Christiane Harenberg; Keerthana Ravichandran; Midhat H Abdulreda; Per-Olof Berggren; Elmar Krause; Claudia Schirra; Trese Leinders-Zufall; Fritz Benseler; Nils Brose; Jens Rettig
Journal:  Elife       Date:  2020-07-22       Impact factor: 8.140
  8 in total

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